Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974593 | 0.88 | KIF11 (0.38) | PTGS2PI4KBPIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974346 | 0.87 | CA1 (0.40) | PTGS2PTGS1KCNH2 | |
| SCHEMBL8973732 | 0.85 | PTGS2 (0.40) | PTGS2PI4KBPIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974112 | 0.82 | CDK9 (0.37) | PTGS2PI4KBPIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974451 | 0.82 | CDK9 (0.37) | PTGS2PI4KBPIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974563 | 0.81 | PTGS2 (0.37) | KDM4EALDH1A1RAB9ASMN1; SMN2PTGS2 | |
| SCHEMBL8973860 | 0.81 | PTGS2 (0.35) | PTGS2PI4KBPIK3CDPIP5K1CPIK3CB | |
| SCHEMBL8974629 | 0.80 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL8974415 | 0.79 | PTGS2 (0.44) | KDM4EMITFALDH1A1LMNASTAT3 | |
| SCHEMBL8974566 | 0.79 | PTGS2 (0.41) | KDM4EMITFALDH1A1LMNASTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | claimed |
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |