Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973775 | 0.90 | KIF11 (0.51) | KIF11PTGS2PTGS1CA12CA2 | |
| SCHEMBL8973789 | 0.88 | KIF11 (0.49) | KIF11PTGS2PTGS1CYP2C9PDE3B | |
| SCHEMBL8974584 | 0.88 | KIF11 (0.55) | KIF11PTGS2PTGS1CA12CA2 | |
| SCHEMBL8974152 | 0.85 | KIF11 (0.56) | KIF11PTGS2PTGS1CA12CA2 | |
| SCHEMBL8974570 | 0.84 | PTGS2 (0.57) | KIF11PTGS2PTGS1CA2CA9 | |
| SCHEMBL8974113 | 0.84 | PTGS2 (0.46) | KIF11PTGS2PTGS1CA12CA2 | |
| SCHEMBL9239696 | 0.84 | PTGS2 (0.47) | KIF11PTGS2PTGS1CA12CA2 | |
| SCHEMBL8974091 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1CA12CA2CA9 | |
| SCHEMBL8974713 | 0.83 | KIF11 (0.72) | KIF11PTGS2PTGS1CA12CA2 | |
| SCHEMBL8974085 | 0.82 | PTGS2 (0.52) | KIF11PTGS2PTGS1CA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |