Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 15/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973743 | 0.89 | KIF11 (0.52) | KIF11PTGS2PTGS1NR1H2CYP2C9 | |
| SCHEMBL8974191 | 0.89 | KIF11 (0.55) | KIF11PTGS2PTGS1NR1H2 | |
| SCHEMBL8974532 | 0.88 | KIF11 (0.48) | KIF11PTGS2PTGS1PDE3BPDE3A | |
| SCHEMBL8974287 | 0.86 | KIF11 (0.56) | KIF11PTGS2PTGS1 | |
| SCHEMBL8974249 | 0.85 | PTGS2 (0.57) | KIF11PTGS2PTGS1NOTUM | |
| SCHEMBL27561072 | 0.84 | KIF11 (0.67) | KIF11PTGS2PTGS1NR1H2NOTUM | |
| SCHEMBL8973748 | 0.84 | KIF11 (0.72) | KIF11PTGS2PTGS1 | |
| SCHEMBL6749827 | 0.83 | KIF11 (0.43) | KIF11PTGS2PTGS1NR1H2PDE3B | |
| SCHEMBL9119695 | 0.83 | PTGS2 (0.61) | KIF11PTGS2PTGS1NR1H2PDE3B | |
| SCHEMBL8974106 | 0.83 | PTGS2 (0.48) | KIF11PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |