Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.34 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973880 | 0.87 | ALOX5 (0.37) | ALOX5PTGS2KDM4EGAARECQL | |
| SCHEMBL8974556 | 0.84 | ELANE (0.39) | SMN1; SMN2ALOX5PTGS2CSNK1A1CSNK1D | |
| SCHEMBL8974841 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2ALOX5PTGS2KDM4EGAA | |
| SCHEMBL8974681 | 0.81 | KDM4E (0.39) | KDM4EGAARECQLPTPN1MEN1 | |
| SCHEMBL11926107 | 0.80 | PTPN1 (0.41) | SMN1; SMN2KDM4EGAARECQLPTPN1 | |
| SCHEMBL9024611 | 0.76 | HRH1 (0.43) | SMN1; SMN2LMNAHRH1HPGDL3MBTL1 | |
| SCHEMBL8974903 | 0.72 | MTNR1A (0.52) | HTR2A | |
| SCHEMBL27655851 | 0.71 | HTR1A (0.36) | SMN1; SMN2ALOX5PTGS2GAAPTPN1 | |
| SCHEMBL15184061 | 0.70 | TSHR (0.39) | ALOX5PTGS2KDM4ELMNA | |
| SCHEMBL2094194 | 0.70 | CYP1A2 (0.47) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0704094-A1 | POLYMERS FOR OPTICAL DEVICES | Cambridge Display Technology Limited (GB) | 1996-04-03 | — | — | EP | disclosed |
| CN-1027064-C | Naphthalene derivatives | EISAI CO LTD (JP) | 1994-12-21 | — | — | CN | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| CN-1043696-A | NAPHTHALENE DERIVATIVES | EISAI CO LTD (JP) | 1990-07-11 | — | — | CN | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |