Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 4/20 | 0.50 |
| ▸ | CES1 | P23141 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.48 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.48 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.48 |
| ▸ | PAM | P19021 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LPAR6 | P43657 | 2/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3113144 | 0.98 | DGKA (0.50) | DGKACES2CES1LMNALPAR1 | |
| SCHEMBL28261297 | 0.98 | DGKA (0.53) | DGKACES2CES1LMNALPAR1 | |
| SCHEMBL3917799 | 0.98 | DGKA (0.53) | DGKACES2CES1LMNALPAR1 | |
| Potassium Ion SCHEMBL7213636 | 0.96 | DGKA (0.52) | DGKACES2CES1LMNALPAR1 | |
| SCHEMBL28072529 | 0.96 | DGKA (0.52) | DGKACES2CES1LMNALPAR1 | |
| SCHEMBL7757135 | 0.89 | DGKA (0.52) | DGKACES2CES1LMNALPAR1 | |
| SCHEMBL338925 | 0.88 | FABP3 (0.57) | LMNALPAR1LPAR4LPAR2LPAR3 | |
| Potassium Ion SCHEMBL7117179 | 0.87 | FABP3 (0.58) | LMNALPAR1LPAR4LPAR2LPAR3 | |
| SCHEMBL31302980 | 0.82 | DGKA (0.57) | DGKACES2CES1LMNAPAM | |
| SCHEMBL11026247 | 0.82 | DGKA (0.57) | DGKACES2CES1LMNAPAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108525023-B | Application of pure magnesium/coating composite material and preparation method thereof | 重庆医科大学附属第三医院(捷尔医院） | 2021-06-15 | — | — | CN | claimed |
| CN-101330943-A | Surface active calcium phosphates | DAVID KANNAR (AU) | 2008-12-24 | — | — | CN | disclosed |
| EP-0547893-B1 | A thermal transfer printing dyesheet | ICI PLC (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5372988-A | Thermal transfer printing dyesheet | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-12-13 | — | — | US | disclosed |
| EP-0547893-A1 | A thermal transfer printing dyesheet | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-23 | — | — | EP | disclosed |