Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973781 | 0.90 | KIF11 (0.59) | PTGS2KIF11MMP1MMP2MMP3 | |
| SCHEMBL8974117 | 0.88 | PTGS2 (0.40) | PTGS2PTGDR2MMP1MMP2MMP3 | |
| SCHEMBL8974421 | 0.88 | PTGS2 (0.43) | PTGS2PTGDR2KIF11PTGS1 | |
| SCHEMBL9117985 | 0.85 | KCNH2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8974198 | 0.85 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL8974837 | 0.84 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL8973759 | 0.83 | POLB (0.41) | PTGS2PTGDR2KIF11MMP1MMP2 | |
| SCHEMBL8974300 | 0.82 | PTGS2 (0.49) | PTGS2AKR1C3MMP1MMP2MMP3 | |
| SCHEMBL8973879 | 0.81 | KIF11 (0.45) | PTGS2KIF11MMP1MMP2MMP3 | |
| SCHEMBL8974645 | 0.80 | PTGS2 (0.57) | PTGS2KIF11AKR1C3PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |