Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 2/20 | 0.37 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.37 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.37 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8975818 | 0.79 | TDP1 (0.42) | TDP1GPR35CA1CA2CA7 | |
| SCHEMBL9688017 | 0.77 | ALDH1A1 (0.39) | TDP1TSHRALDH1A1TXNRD1TXNRD3 | |
| SCHEMBL8885657 | 0.76 | CA1 (0.33) | CA1CA2CA7CA9S100A4 | |
| SCHEMBL18253145 | 0.74 | NQO1 (0.37) | TDP1TSHRALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL3058540 | 0.73 | TDP1 (0.42) | TDP1GPR35CA1CA2TSHR | |
| SCHEMBL7465992 | 0.71 | TDP1 (0.33) | TDP1GPR35CA1CA2CA7 | |
| SCHEMBL10689193 | 0.71 | TDP1 (0.41) | TDP1GPR35CA1CA2CA7 | |
| Ethane SCHEMBL28101016 | 0.71 | TDP1 (0.52) | TDP1GPR35TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL30677836 | 0.70 | FFAR4 (0.37) | ACHE | |
| SCHEMBL15009561 | 0.69 | AHR (0.47) | TDP1GPR35TSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537518-B1 | Derivatives of 2,2-dihalobenzo(1,3)dioxoles substituted in the 4-position, methods for their preparation and their use | BAYER AG (DE) | 1996-04-17 | — | — | EP | disclosed |
| US-5281725-A | Derivatives of 2,2-dihalogenobenzo[1,3]dioxoles substituted in the 4-position, processes for their preparation and their use | BAYER AKTIENGESELLSCHAFT (DE) | 1994-01-25 | — | — | US | disclosed |
| EP-0537518-A1 | Derivatives of 2,2-dihalobenzo(1,3)dioxoles substituted in the 4-position, methods for their preparation and their use | BAYER AG (DE) | 1993-04-21 | — | — | EP | disclosed |