Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | ELANE | P08246 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507612 | 0.77 | PARP1 (0.54) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1584889 | 0.75 | PIM1 (0.56) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL3795673 | 0.75 | IP6K1 (0.56) | IP6K1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL31361978 | 0.75 | IP6K1 (0.56) | IP6K1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL8622177 | 0.75 | ACVR1 (0.46) | IP6K1PDE3BPDE3AMEN1NPC1 | |
| SCHEMBL2191063 | 0.74 | PARP1 (0.54) | KDM4EKMT2AALDH1A1GAAGLA | |
| SCHEMBL2191001 | 0.74 | PARP1 (0.54) | ALDH1A1GAAHPGD | |
| SCHEMBL216175 | 0.74 | PARP1 (0.54) | MEN1KMT2AALDH1A1QPCTMAPT | |
| SCHEMBL8700858 | 0.74 | PARP1 (0.54) | KDM4EARNPC1RAB9AALDH1A1 | |
| SCHEMBL2574527 | 0.74 | LMNA (0.57) | KDM4EMEN1KMT2AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |