Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2191216 | 0.85 | ALDH1A1 (0.55) | PARP1ALDH1A1RXFP1PIM1GSK3A | |
| SCHEMBL1584889 | 0.79 | PIM1 (0.56) | ALDH1A1PIM1GSK3AGSK3BDYRK1A | |
| SCHEMBL8622177 | 0.79 | ACVR1 (0.46) | PARP1ALDH1A1PIM1PIM3HPGD | |
| SCHEMBL1507612 | 0.78 | PARP1 (0.54) | PARP1ALDH1A1RXFP1PIM1LMNA | |
| SCHEMBL2574527 | 0.78 | LMNA (0.57) | PARP1ALDH1A1LMNACYP1A2GAA | |
| SCHEMBL216175 | 0.78 | PARP1 (0.54) | PARP1ALDH1A1PIM1GSK3AGSK3B | |
| SCHEMBL8700858 | 0.78 | PARP1 (0.54) | PARP1ALDH1A1CSNK2A1HPGDRPS6KA3 | |
| SCHEMBL2191063 | 0.78 | PARP1 (0.54) | PARP1ALDH1A1GPR84GAACHEK1 | |
| SCHEMBL29953175 | 0.77 | ENPP2 (0.39) | PARP1ALDH1A1PIM1PIM3LMNA | |
| SCHEMBL2723600 | 0.77 | ENPP2 (0.39) | PARP1ALDH1A1PIM1PIM3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107337646-B | Method for synthesizing quinazolinone derivative by using methanol as raw material | 南京理工大学 | 2020-04-07 | — | — | CN | disclosed |
| US-8173806-B2 | Method for production of quinazolin-4-one derivative | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2012-05-08 | — | — | US | disclosed |
| EP-1466907-B1 | PROCESS FOR PRODUCING QUINAZOLIN-4-ONE AND DERIVATIVE THEREOF | UBE INDUSTRIES (JP) | 2011-08-10 | — | — | EP | disclosed |
| EP-1997812-B1 | METHOD FOR PRODUCTION OF QUINAZOLIN-4-ON DERIVATIVE | MITSUBISHI GAS CHEMICAL CO (JP) | 2011-07-13 | — | — | EP | disclosed |
| US-20090054646-A1 | Method for Production of Quinazolin 4-One Derivative | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1997812-A1 | METHOD FOR PRODUCTION OF QUINAZOLIN-4-ON DERIVATIVE | Mitsubishi Gas Chemical Company, Inc. (JP) | 2008-12-03 | — | — | EP | disclosed |
| US-7232903-B2 | Process for producing quinazolin-4-one and derivatives thereof | UBE INDUSTRIES, LTD. (JP) | 2007-06-19 | — | — | US | disclosed |
| US-20050124809-A1 | Process for producing quinazolin-4-one and derivatives thereof | UBE INDUSTRIES, LTD. (JP) | 2005-06-09 | — | — | US | disclosed |
| US-20050107409-A1 | Aromatic bicyclic compounds, preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-05-19 | — | — | US | disclosed |
| EP-1466907-A1 | PROCESS FOR PRODUCING QUINAZOLIN-4-ONE AND DERIVATIVE THEREOF | Ube Industries, Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124809-A1 | Process for producing quinazolin-4-one and derivatives thereof | ASNS, NQO2, KYNU | PARP1 1136/4885ALDH1A1 2564/4885RXFP1 2112/4885 |
| US-20050107409-A1 | Aromatic bicyclic compounds, preparation thereof and their use as pharmaceutical compositions | F12, F2, F11 | PARP1 389/4885ALDH1A1 1078/4885RXFP1 460/4885 |
| US-20090054646-A1 | Method for Production of Quinazolin 4-One Derivative | NQO2, ALDH7A1, ALAD | PARP1 2157/4885ALDH1A1 314/4885RXFP1 1001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.