Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | NGFR | P08138 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663769 | 0.85 | PRKCI (0.56) | PARP1PRKCIMAPTKDM4ERAD52 | |
| SCHEMBL8622177 | 0.79 | ACVR1 (0.46) | PARP1MAPTCA12CA9HPGD | |
| SCHEMBL1584889 | 0.79 | PIM1 (0.56) | MAPTRPS6KA3CSNK2A1HPGDCLK1 | |
| SCHEMBL2574527 | 0.78 | LMNA (0.57) | PARP1MAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL2191063 | 0.78 | PARP1 (0.54) | PARP1KDM4ECYP2C19ALDH1A1 | |
| SCHEMBL1507612 | 0.78 | PARP1 (0.54) | PARP1KDM4ERPS6KA3HPGDALDH1A1 | |
| SCHEMBL216175 | 0.78 | PARP1 (0.54) | PARP1MAPTHPGDEGFRALDH1A1 | |
| SCHEMBL2191001 | 0.78 | PARP1 (0.54) | PARP1RPS6KA3CSNK2A1CA12CA9 | |
| SCHEMBL6886180 | 0.77 | XDH (0.36) | PARP1PRKCIMAPTKDM4ERAD52 | |
| SCHEMBL11584004 | 0.77 | ATIC (0.42) | PARP1PRKCIMAPTKDM4ERAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121574623-A | Corrosion-resistant and wear-resistant coating for electromagnetic valve armature core of shock absorber and preparation method thereof | 时硕科技(无锡)有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-4997920-A | Dyeing polyolefins | CIBA-GEIGY CORPORATION (US) | 1991-03-05 | — | — | US | claimed |
| US-4670486-A | Polymer composition pigmented with copper or nickel complexes of ligands containing a semicarbazone moiety | CIBA-GEIGY CORPORATION (US) | 1987-06-02 | — | — | US | claimed |
| CN-121574623-A | Corrosion-resistant and wear-resistant coating for electromagnetic valve armature core of shock absorber and preparation method thereof | 时硕科技(无锡)有限公司 | 2026-02-27 | — | — | CN | disclosed |
| EP-4073044-B1 | NEW BRAF INHIBITORS AS PARADOX BREAKERS | HOFFMANN LA ROCHE (CH) | 2025-02-19 | — | — | EP | disclosed |
| CN-114746405-B | Novel BRAF inhibitors as anomalous breakers | 豪夫迈·罗氏有限公司 | 2024-03-26 | — | — | CN | disclosed |
| US-20220298145-A1 | BRAF INHIBITORS AS PARADOX BREAKERS | HOFFMANN-LA ROCHE INC. (US) | 2022-09-22 | — | — | US | disclosed |
| CN-114746405-A | Novel BRAF inhibitors as paradoxical breakers | 豪夫迈·罗氏有限公司 | 2022-07-12 | — | — | CN | disclosed |
| WO-2021116050-A1 | NEW BRAF INHIBITORS AS PARADOX BREAKERS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-06-17 | — | — | WO | disclosed |
| US-5817832-A | Blue diketopyrrolopyrrole pigments | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-10-06 | — | — | US | disclosed |
| US-5409926-A | Inhibiting the side effect from angioplasty surgery by administering a biphenyl methyl-6-aminoquinazolinones | MERCK & CO., INC. (US) | 1995-04-25 | — | — | US | disclosed |
| US-4263205-A | FOR COLORING POLYMERS, LACQUERS | CIBA-GEIGY CORPORATION (US) | 1981-04-21 | — | — | US | disclosed |
| US-4262120-A | YELLOW TO ORANGE SHADES OF GOOD FASTNESS | CIBA-GEIGY CORPORATION (US) | 1981-04-14 | — | — | US | disclosed |
| US-4220586-A | FASTNESS TO LIGHT, OVER-LACQUERING, MIGRATION, WEATHERING, AND HEAT | CIBA-GEIGY CORPORATION (US) | 1980-09-02 | — | — | US | disclosed |
| EP-0000737-A1 | Monoazo pigments of the acetoacetylamino benzimidazolone series, their preparation and their use for colouring organic material of high molecular weight | CIBA-GEIGY AG (CH) | 1979-02-21 | — | — | EP | disclosed |
| US-4116959-A | ISOINDOLINE PIGMENTS | CIBA-GEIGY CORPORATION (US) | 1978-09-26 | — | — | US | disclosed |
| US-4088641-A | YELLOW TO RED SHADES | CIBA-GEIGY CORPORATION (US) | 1978-05-09 | — | — | US | disclosed |
| US-4052410-A | YELLOW, PLASTICS, LACQUERS | CIBA-GEIGY CORPORATION (US) | 1977-10-04 | — | — | US | disclosed |
| US-3979386-A | YELLOW, COLORFASTNESS | CIBA-GEIGY CORPORATION (US) | 1976-09-07 | — | — | US | disclosed |
| US-3956266-A | DISAZO DYES | CIBA-GEIGY CORPORATION (US) | 1976-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220298145-A1 | BRAF INHIBITORS AS PARADOX BREAKERS | BRAF, NRAS, RAF1 | PARP1 616/4885PRKCI 298/4885MAPT 3939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.