SCHEMBL8976990

SCHEMBL8976990

COc1ccc(C(=O)/C(C#N)=C/c2ccc(O)cc2)cc1C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.56
KMT2A Q03164 5/20 0.56
MAPT P10636 5/20 0.56
MEN1 O00255 4/20 0.56
CYP1A2 P05177 3/20 0.56
KDM4E B2RXH2 3/20 0.56
CYP3A4 P08684 3/20 0.56
HPGD P15428 3/20 0.56
POLB P06746 3/20 0.56
RGS12 O14924 2/20 0.56
USP2 O75604 2/20 0.56
ALPL P05186 2/20 0.56
ALPI P09923 2/20 0.56
ALPG P10696 2/20 0.56
ALOX15 P16050 2/20 0.56
ALOX12 P18054 2/20 0.56
APEX1 P27695 2/20 0.56
MAPK1 P28482 2/20 0.56
RECQL P46063 2/20 0.56
BLM P54132 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8976999 1.00 ALDH1A1 (0.56) ALDH1A1KMT2AMAPTMEN1CYP1A2
SCHEMBL8965213 0.93 EGFR (0.57) ALDH1A1KMT2AMAPTMEN1CYP1A2
SCHEMBL8965373 0.82 CYP1A2 (0.53) ALDH1A1KMT2AMAPTMEN1CYP1A2
SCHEMBL8976998 0.81 ALDH1A1 (0.55) ALDH1A1KMT2AMAPTMEN1CYP1A2
SCHEMBL8976994 0.81 ALDH1A1 (0.55) ALDH1A1KMT2AMAPTMEN1CYP1A2
SCHEMBL8965376 0.81 ALDH1A1 (0.55) ALDH1A1KMT2AMAPTMEN1CYP1A2
SCHEMBL8964945 0.78 MEN1 (0.59) ALDH1A1KMT2AMAPTMEN1CYP1A2
SCHEMBL3428284 0.76 ALDH1A1 (0.64) ALDH1A1KMT2AMAPTMEN1CYP1A2
SCHEMBL3428282 0.76 ALDH1A1 (0.64) ALDH1A1KMT2AMAPTMEN1CYP1A2
SCHEMBL13936216 0.73 CYP1A2 (0.69) ALDH1A1KMT2AMAPTMEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0428398-B1 Radiation-sensitive resin composition JAPAN SYNTHETIC RUBBER CO LTD (JP) 1996-04-03 EP claimed
EP-0428398-A2 Radiation-sensitive resin composition JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1991-05-22 EP claimed
EP-0428398-B1 Radiation-sensitive resin composition JAPAN SYNTHETIC RUBBER CO LTD (JP) 1996-04-03 EP disclosed
US-5110706-A Photoresists for highly reflective substrates JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1992-05-05 US disclosed
EP-0428398-A2 Radiation-sensitive resin composition JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1991-05-22 EP disclosed