SCHEMBL8977221

SCHEMBL8977221

Cc1ccc(-n2nn[nH]c2=O)cc1C

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
CA1 P00915 3/20 0.43
CA2 P00918 3/20 0.43
ALDH1A1 P00352 4/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
HCAR1 Q9BXC0 1/20 0.41
LMNA P02545 3/20 0.40
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
STAT1 P42224 1/20 0.40
GAA P10253 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
XBP1 P17861 1/20 0.40
ALKBH5 Q6P6C2 1/20 0.39
ADRB1 P08588 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5906191 0.80 ALDH1A1 (0.42) SMN1; SMN2NPC1RAB9AALDH1A1KMT2A
SCHEMBL5905967 0.78 CYP1A2 (0.48) NPC1RAB9AALDH1A1LMNAMAPT
SCHEMBL8599564 0.77 HSP90AA1 (0.39) SMN1; SMN2ALDH1A1MEN1KMT2AHCAR1
SCHEMBL5906345 0.76 GAA (0.47) SMN1; SMN2ALDH1A1LMNAMAPTHTT
SCHEMBL17938252 0.75 RAB9A (0.50) SMN1; SMN2NPC1RAB9AALDH1A1LMNA
SCHEMBL8977290 0.75 HSD17B10 (0.50) SMN1; SMN2NPC1RAB9AALDH1A1KMT2A
SCHEMBL17946008 0.73 CYP2C9 (0.40) KMT2ACYP1A2
SCHEMBL5905977 0.73 GAA (0.42) SMN1; SMN2NPC1RAB9AMEN1KMT2A
SCHEMBL5906067 0.73 IDO1 (0.41) CA1CA2ALDH1A1KMT2AHCAR1
SCHEMBL5906174 0.73 NPC1 (0.42) SMN1; SMN2NPC1RAB9ACA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0708097-A1 Herbicidally active tetrazolinones NIHON BAYER AGROCHEM K.K. (JP) 1996-04-24 EP disclosed