Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16490973 | 0.84 | CYP1A2 (0.35) | CYP1A2POLBCYP3A4MAPTLMNA | |
| SCHEMBL8599564 | 0.82 | HSP90AA1 (0.39) | CYP1A2POLBMAPTLMNAALDH1A1 | |
| SCHEMBL3239509 | 0.81 | IDO1 (0.46) | CYP1A2CYP3A4TP53ALDH1A1IDO1 | |
| SCHEMBL18504147 | 0.81 | CYP1A2 (0.56) | CYP1A2MAPTLMNATP53L3MBTL1 | |
| SCHEMBL18503917 | 0.80 | FAAH (0.46) | CYP1A2POLBCYP3A4MGLL | |
| SCHEMBL16297129 | 0.80 | IDO1 (0.47) | POLBMAPTL3MBTL1ALDH1A1IDO1 | |
| SCHEMBL18849418 | 0.80 | CYP1A2 (0.32) | CYP1A2POLBCYP3A4L3MBTL1IDO1 | |
| SCHEMBL22564074 | 0.80 | MGLL (0.46) | L3MBTL1ALDH1A1MGLLNPBWR1ALOX5 | |
| SCHEMBL17938253 | 0.80 | TSHR (0.44) | CYP3A4MAPTALDH1A1 | |
| SCHEMBL18504537 | 0.80 | CTSK (0.42) | CYP3A4MAPTTP53ALDH1A1NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2841429-B1 | TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES | SUMITOMO CHEMICAL CO (JP) | 2020-10-21 | — | — | EP | disclosed |
| US-20180002297-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2018-01-04 | — | — | US | disclosed |
| EP-2833889-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2017-11-01 | — | — | EP | disclosed |
| US-9701647-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-9701647-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-20170129862-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2017-05-11 | — | — | US | disclosed |
| US-9565856-B2 | Tetrazolinone compounds and its use as pesticides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-02-14 | — | — | US | disclosed |
| US-9439888-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-20160213648-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2016-07-28 | — | — | US | disclosed |
| US-9321763-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| WO-2013152198-A1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS, INC. (US) | 2013-10-10 | — | — | WO | disclosed |
| US-20060223872-A1 | Insecticidal phthalamide derivatives | BAYER CROPSCIENCE AG (DE) | 2006-10-05 | — | — | US | disclosed |
| US-5767286-A | REACTING A TETRAZOLINONE WITH A CARBAMOYL CHLORIDE IN THE PRESENCE OF 4-DIMETHYLAMINOPYRIDINE | NIHON BAYER AGROCHEM K. K. (JP) | 1998-06-16 | — | — | US | disclosed |
| EP-0646577-B1 | Process for the preparation of 1,4-disubstituted-5(4H)-tetrazolinones | BAYER AGROCHEM KK (JP) | 1998-06-03 | — | — | EP | disclosed |
| EP-0643049-B1 | A process for the preparation of 1-substituted-5(4H)-tetrazolinones | BAYER AGROCHEM KK (JP) | 1997-05-14 | — | — | EP | disclosed |
| US-5502204-A | REACTING WITH ETHYLENE OXIDE DERIVATIVE | NIHON BAYER AGROCHEM K.K. (JP) | 1996-03-26 | — | — | US | disclosed |
| EP-0646577-A1 | Process for the preparation of 1,4-disubstituted-5(4H)-tetrazolinones | NIHON BAYER AGROCHEM K.K. (JP) | 1995-04-05 | — | — | EP | disclosed |
| EP-0643049-A1 | A process for the preparation of 1-substituted-5(4H)-tetrazolinones | NIHON BAYER AGROCHEM K.K. (JP) | 1995-03-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170129862-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | CYP1A2 429/4885POLB 2144/4885CYP3A4 386/4885 |
| US-20060223872-A1 | Insecticidal phthalamide derivatives | CRYAA, PRXL2A, H1-2 | CYP1A2 607/4885POLB 4402/4885CYP3A4 2896/4885 |
| US-20160213648-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | CYP1A2 429/4885POLB 2144/4885CYP3A4 386/4885 |
| US-20180002297-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | CYP1A2 429/4885POLB 2144/4885CYP3A4 386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.