SCHEMBL8977332

SCHEMBL8977332

Fc1cc2[nH]c(Cl)nc2cc1-n1cccc1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
OPRL1 P41146 12/20 0.37
CYP11B2 P19099 1/20 0.33
CBFB Q13951 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
HPGD P15428 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSD17B10 Q99714 1/20 0.33
EGLN1 Q9GZT9 1/20 0.32
PDE10A Q9Y233 1/20 0.32
CYP19A1 P11511 1/20 0.32
GRIA1 P42261 1/20 0.32
GRIA2 P42262 1/20 0.32
GRIA3 P42263 1/20 0.32
GRIA4 P48058 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8977340 0.94 GRIA1 (0.35) OPRL1CYP11B2CBFBKDM4EALDH1A1
SCHEMBL8977368 0.81 OPRL1 (0.37) OPRL1CYP11B2CBFBKDM4EALDH1A1
SCHEMBL1193108 0.77 ALDH1A1 (0.49) CYP11B2CBFBKDM4EALDH1A1CYP1A2
SCHEMBL8977372 0.75 GRIA1 (0.35) OPRL1CYP11B2CBFBKDM4EALDH1A1
SCHEMBL8977359 0.75 OPRL1 (0.36) OPRL1
SCHEMBL1193135 0.74 MAPT (0.52) CBFBKDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL8470034 0.71 CBFB (0.42) CBFBKDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL8470028 0.71 POLB (0.40) CBFBKDM4EALDH1A1HPGDHSD17B10
SCHEMBL1440759 0.71 ALDH1A1 (0.47) CBFBKDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL12844638 0.68 FABP6 (0.43) KDM4EALDH1A1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5554631-A ANTIULCER IL-YANG PHARM. CO., LTD. (KR) 1996-09-10 US disclosed