SCHEMBL8977675

SCHEMBL8977675

CSC(=S)Nc1ccc(Cl)cc1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.53
KDM4E B2RXH2 2/20 0.53
ALDH1A1 P00352 4/20 0.53
GAA P10253 1/20 0.53
KMT2A Q03164 3/20 0.53
TSHR P16473 1/20 0.52
EPHX1 P07099 1/20 0.52
NOX1 Q9Y5S8 1/20 0.50
SMN1; SMN2 Q16637 4/20 0.48
RAB9A P51151 3/20 0.48
NPC1 O15118 2/20 0.48
MEN1 O00255 2/20 0.48
HTT P42858 1/20 0.48
NLRP1 Q9C000 1/20 0.48
LMNA P02545 2/20 0.47
CNR1 P21554 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19101057 0.89 KDM4E (0.62) MAPTKDM4EALDH1A1GAAKMT2A
SCHEMBL28796269 0.80 KMT2A (0.67) MAPTKDM4EALDH1A1GAAKMT2A
SCHEMBL10189868 0.77 EPHX1 (0.60) MAPTKDM4EALDH1A1GAAKMT2A
SCHEMBL1286315 0.77 PHGDH (0.71) MAPTKDM4EALDH1A1GAAKMT2A
SCHEMBL5445907 0.77 MAPT (0.75) MAPTKDM4EALDH1A1GAAKMT2A
SCHEMBL8956455 0.77 MAPT (0.75) MAPTKDM4EALDH1A1GAAKMT2A
Hydrochloric Acid SCHEMBL27651012 0.76 PHGDH (0.68) MAPTKDM4EALDH1A1GAAKMT2A
SCHEMBL8103753 0.75 RAB9A (0.54) MAPTKDM4EALDH1A1KMT2ASMN1; SMN2
SCHEMBL8531717 0.75 MAPT (0.64) MAPTKDM4EALDH1A1GAAKMT2A
SCHEMBL23752147 0.75 NOX1 (0.61) MAPTKDM4EALDH1A1GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5510344-A Acrylate fungicides SCHERING AGROCHEMICALS LIMITED (GB) 1996-04-23 US disclosed
EP-0378308-B1 Acrylate fungicides AGREVO UK LTD (GB) 1996-04-10 EP disclosed
US-5332752-A Acrylate fungicides SCHERING AGROCHEMICALS LIMITED (GB) 1994-07-26 US disclosed
EP-0378308-A1 Acrylate fungicides AgrEvo UK Limited (GB) 1990-07-18 EP disclosed