Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168470 | 0.78 | MEN1 (0.41) | ALDH1A1SMN1; SMN2RAB9AKDM4ENPC1 | |
| SCHEMBL10106909 | 0.76 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2RAB9AKDM4EALOX15 | |
| SCHEMBL13799417 | 0.76 | HRH3 (0.54) | TDP1POLBGABRA1GABRB2ALDH1A1 | |
| SCHEMBL25954061 | 0.76 | ELANE (0.46) | TDP1ALDH1A1SMN1; SMN2ALOX15LMNA | |
| SCHEMBL164160 | 0.76 | ELANE (0.46) | TDP1ALDH1A1SMN1; SMN2ALOX15LMNA | |
| SCHEMBL25954066 | 0.73 | ELANE (0.40) | TDP1ALDH1A1GAASMN1; SMN2RAB9A | |
| SCHEMBL9114928 | 0.73 | TDP1 (0.40) | TDP1POLBGABRA1GABRB2ALDH1A1 | |
| SCHEMBL7816085 | 0.72 | KDM4E (0.42) | ALDH1A1KDM4ECLK1DYRK1ADYRK1B | |
| SCHEMBL25954105 | 0.71 | ESR2 (0.48) | ALDH1A1SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL25954134 | 0.71 | ELANE (0.42) | TDP1ALDH1A1SMN1; SMN2RAB9AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5573712-A | PHOTOCHROMIC ARTICLE COMPRISING ORGANIC HOST AND THE PHOTOCHROMIC NAPHTHOPYRAN | TRANSITIONS OPTICAL, INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5552090-A | Photochromic naphthopyran compounds | PPG INDUSTRIES, INC. (US) | 1996-09-03 | — | — | US | disclosed |
| US-5458814-A | Ophthalmic lenses | TRANSITIONS OPTICAL, INC. (US) | 1995-10-17 | — | — | US | disclosed |