SCHEMBL8978690

SCHEMBL8978690

Nc1ccc(C(=O)Nc2ccc(-c3ccc(NC(=O)c4ccc(N)cc4)c(O)c3)cc2O)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 8/20 0.67
MAPT P10636 6/20 0.56
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
GAA P10253 2/20 0.56
POLB P06746 2/20 0.54
NPC1 O15118 1/20 0.54
RAB9A P51151 1/20 0.54
LMNA P02545 1/20 0.53
PKM P14618 1/20 0.53
APEX1 P27695 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
HDAC2 Q92769 3/20 0.50
MAPK1 P28482 1/20 0.50
CYP1A2 P05177 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
HDAC3 O15379 1/20 0.49
SNCA P37840 1/20 0.49
ALDH1A1 P00352 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31499393 1.00 HDAC1 (0.67) HDAC1MAPTMEN1KMT2AGAA
SCHEMBL13601067 0.87 HDAC1 (0.86) HDAC1MEN1KMT2APOLBLMNA
SCHEMBL16444808 0.86 HDAC1 (0.65) HDAC1MAPTMEN1KMT2AGAA
SCHEMBL13721324 0.85 MAPT (0.56) HDAC1MAPTMEN1KMT2APOLB
SCHEMBL13601076 0.84 HDAC1 (0.63) HDAC1MAPTMEN1KMT2AGAA
SCHEMBL19846838 0.83 ALDH1A1 (0.66) HDAC1MAPTMEN1KMT2AGAA
SCHEMBL22905311 0.83 HDAC1 (0.71) HDAC1MAPTMEN1KMT2AGAA
SCHEMBL20584437 0.83 HDAC1 (0.71) HDAC1MAPTMEN1KMT2AGAA
SCHEMBL9135648 0.82 MAPT (0.68) HDAC1MAPTMEN1KMT2AGAA
SCHEMBL28803930 0.82 MAPT (0.52) HDAC1MAPTMEN1KMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5494991-A REACTING TETRACARBOXYLIC DIANHYDRIDE WITH AROMATIC DIAMINE, HAVING AMIDE AND HYDROXYL GROUPS WHICH DEHYDRATE TO FORM BENZOXAZOLE RING WITHIN THE DIAMINE SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-02-27 US claimed
US-20230106477-A1 COMPOSITE, SLURRY COMPOSITION, FILM, AND METAL-CLAD LAMINATE ENEOS CORPORATION (JP) 2023-04-06 US disclosed
EP-3919549-A1 COMPOSITION AND METAL-INSULATING COATING MATERIAL Mitsubishi Chemical Corporation (JP) 2021-12-08 EP disclosed
US-20210324144-A1 COMPOSITION AND METAL INSULATING COVER MATERIAL MITSUBISHI CHEMICAL CORPORATION (JP) 2021-10-21 US disclosed
US-20210122724-A1 TETRACARBOXYLIC DIANHYDRIDE, CARBONYL COMPOUND, POLYIMIDE PRECURSOR RESIN, AND POLYIMIDE ENEOS CORPORATION (JP) 2021-04-29 US disclosed
US-10947353-B2 Resin composition MITSUBISHI CHEMICAL CORPORATION (JP) 2021-03-16 US disclosed
WO-2020158736-A1 COMPOSITION AND METAL-INSULATING COATING MATERIAL 三菱ケミカル株式会社 2020-08-06 WO disclosed
EP-3438992-A1 RESIN COMPOSITION Mitsubishi Chemical Corporation (JP) 2019-02-06 EP disclosed
US-20190031844-A1 RESIN COMPOSITION MITSUBISHI CHEMICAL CORPORATION (JP) 2019-01-31 US disclosed
US-20180362763-A1 RESIN COMPOSITION, METHOD FOR PRODUCING RESIN, METHOD FOR PRODUCING RESIN FILM, AND METHOD FOR PRODUCING ELECTRONIC DEVICE TORAY INDUSTRIES, INC. (JP) 2018-12-20 US disclosed
EP-2540759-B1 Thermosetting resin composition and cured product of the same DAINIPPON INK & CHEMICALS (JP) 2014-08-06 EP disclosed
EP-2436734-B1 THERMOSETTING RESIN COMPOSITE AND CURED PRODUCT THEREOF DAINIPPON INK & CHEMICALS (JP) 2014-07-23 EP disclosed
US-8470913-B2 Thermosetting resin composition and cured product of the same DIC CORPORATION (JP) 2013-06-25 US disclosed
EP-2540759-A2 Thermosetting resin composition and cured product of the same DIC Corporation (JP) 2013-01-02 EP disclosed
US-20120142829-A1 THERMOSETTING RESIN COMPOSITION AND CURED PRODUCT OF THE SAME DIC CORPORATION (JP) 2012-06-07 US disclosed
US-5494991-A REACTING TETRACARBOXYLIC DIANHYDRIDE WITH AROMATIC DIAMINE, HAVING AMIDE AND HYDROXYL GROUPS WHICH DEHYDRATE TO FORM BENZOXAZOLE RING WITHIN THE DIAMINE SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-02-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210122724-A1 TETRACARBOXYLIC DIANHYDRIDE, CARBONYL COMPOUND, POLYIMIDE PRECURSOR RESIN, AND POLYIMIDE EXOSC4, RIN1, EXOSC5 HDAC1 961/4885MAPT 3011/4885MEN1 759/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.