Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL820669 | 0.79 | ACHE (0.52) | MTNR1AMTNR1BHSD17B2HSD17B1ACHE | |
| SCHEMBL30054343 | 0.79 | MTNR1A (0.61) | MTNR1AMTNR1BHSD17B2HSD17B1ACHE | |
| SCHEMBL29636366 | 0.79 | ACHE (0.52) | MTNR1AMTNR1BHSD17B2HSD17B1ACHE | |
| SCHEMBL1134082 | 0.79 | MTNR1A (0.61) | MTNR1AMTNR1BHSD17B2HSD17B1ACHE | |
| SCHEMBL4547158 | 0.79 | CETP (0.44) | SLC6A4 | |
| Hydrochloric Acid SCHEMBL2861521 | 0.78 | HSD17B2 (0.50) | MTNR1AMTNR1BHSD17B2HSD17B1ACHE | |
| SCHEMBL31256052 | 0.77 | ACHE (0.54) | MTNR1AMTNR1BHSD17B2HSD17B1ACHE | |
| SCHEMBL20979821 | 0.77 | ACHE (0.54) | MTNR1AMTNR1BHSD17B2HSD17B1ACHE | |
| SCHEMBL4763030 | 0.76 | MTNR1A (0.50) | MTNR1AMTNR1BHSD17B2HSD17B1ACHE | |
| SCHEMBL19725014 | 0.76 | ALDH1A1 (0.52) | MTNR1AMTNR1BHSD17B2HSD17B1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188097-B2 | Pyrazolo[1,5-A]pyrimidine compounds | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-05-29 | — | — | US | disclosed |
| US-8188097-B2 | Pyrazolo[1,5-A]pyrimidine compounds | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-05-29 | — | — | US | disclosed |
| US-20090069298-A1 | Pyrazolo[1,5-A]Pyrimidine Compounds | TANABE SEIYAKU CO., LTD. (JP) | 2009-03-12 | — | — | US | disclosed |
| US-20090069298-A1 | Pyrazolo[1,5-A]Pyrimidine Compounds | TANABE SEIYAKU CO., LTD. (JP) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069298-A1 | Pyrazolo[1,5-A]Pyrimidine Compounds | RECQL, QTRT1, DPYD | MTNR1A 719/4885MTNR1B 734/4885SLC6A2 3051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.