Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.40 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.40 |
| ▸ | INPP5A | Q14642 | 2/20 | 0.40 |
| ▸ | INPP5B | P32019 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL3694039 | 0.89 | KMT2A (0.38) | S1PR1S1PR3ALDH1A1KMT2AMEN1 | |
| SCHEMBL29613140 | 0.86 | INPPL1 (0.52) | INPPL1INPP5AINPP5BALDH1A1SRC | |
| SCHEMBL224271 | 0.86 | INPPL1 (0.52) | INPPL1INPP5AINPP5BALDH1A1SRC | |
| Phosphoric Acid SCHEMBL7921303 | 0.85 | INPPL1 (0.50) | INPPL1INPP5AINPP5BALDH1A1SRC | |
| Benzene SCHEMBL27478938 | 0.85 | KDM4E (0.53) | INPPL1INPP5AINPP5BALDH1A1SRC | |
| Tromethamine SCHEMBL5669990 | 0.81 | INPPL1 (0.43) | S1PR1S1PR3INPPL1INPP5AINPP5B | |
| Tromethamine SCHEMBL284296 | 0.78 | LMNA (0.53) | S1PR1S1PR3INPPL1INPP5AINPP5B | |
| Tromethamine SCHEMBL5906711 | 0.78 | INPPL1 (0.43) | S1PR1S1PR3INPPL1INPP5AINPP5B | |
| Tromethamine SCHEMBL22471800 | 0.78 | TSHR (0.39) | S1PR1S1PR3ALDH1A1KDM4ELMNA | |
| Tromethamine SCHEMBL2443257 | 0.77 | KDM4E (0.45) | S1PR1S1PR3INPPL1INPP5AINPP5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707081-A1 | Methods for quenching metal | FMC CORPORATION (US) | 1996-04-17 | — | — | EP | claimed |
| US-5490886-A | USING ORGANIC PHOSPHATE ESTER | FMC CORPORATION (US) | 1996-02-13 | — | — | US | claimed |
| EP-3642252-A1 | LATENT CURING AGENT AND CURABLE POLYURETHANE COMPOSITION | Sika Technology AG (CH) | 2020-04-29 | — | — | EP | disclosed |
| EP-2540772-B1 | WEATHER-RESISTANT VINYL CHLORIDE RESIN COMPOSITION | ADEKA CORP (JP) | 2017-03-29 | — | — | EP | disclosed |
| EP-2540772-A1 | WEATHER-RESISTANT VINYL CHLORIDE RESIN COMPOSITION | Adeka Corporation (JP) | 2013-01-02 | — | — | EP | disclosed |
| US-20120316274-A1 | WEATHER RESISTANT VINYL CHLORIDE RESIN COMPOSITION | ADEKA CORPORATION (JP) | 2012-12-13 | — | — | US | disclosed |