Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | INPPL1 | O15357 | 3/20 | 0.43 |
| ▸ | INPP5A | Q14642 | 3/20 | 0.43 |
| ▸ | INPP5B | P32019 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127225 | 0.85 | LMNA (0.64) | LMNASMN1; SMN2INPPL1INPP5AINPP5B | |
| Hydrochloric Acid SCHEMBL29188656 | 0.83 | LMNA (0.62) | LMNASMN1; SMN2INPPL1INPP5AINPP5B | |
| Tromethamine SCHEMBL5669990 | 0.81 | INPPL1 (0.43) | INPPL1INPP5AINPP5BHPGDSRC | |
| Tromethamine SCHEMBL5906711 | 0.81 | INPPL1 (0.43) | LMNASMN1; SMN2INPPL1INPP5AINPP5B | |
| Tromethamine SCHEMBL2443257 | 0.80 | KDM4E (0.45) | LMNASMN1; SMN2INPPL1INPP5AINPP5B | |
| Tromethamine SCHEMBL8979418 | 0.78 | S1PR1 (0.40) | LMNAINPPL1INPP5AINPP5BHPGD | |
| SCHEMBL28854947 | 0.76 | LMNA (0.50) | LMNASMN1; SMN2INPPL1INPP5AINPP5B | |
| Tromethamine SCHEMBL5668904 | 0.76 | MAPT (0.55) | LMNAINPPL1INPP5AINPP5BHPGD | |
| Tromethamine SCHEMBL3236196 | 0.76 | S1PR1 (0.51) | S1PR1S1PR3 | |
| Tromethamine SCHEMBL7627157 | 0.76 | S1PR1 (0.51) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 161 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116659004-B | Air conditioner | DAIKIN INDUSTRIES, LTD. (JP) | 2026-05-26 | — | — | CN | disclosed |
| CN-116731775-B | Refrigerating cycle device, refrigerating machine oil, and refrigerant leakage preventing agent | 大金工业株式会社 | 2025-02-18 | — | — | CN | disclosed |
| CN-118434786-A | Imide-containing polyols, methods for preparing imide-containing polyols, and methods of using imide polyols | 陶氏环球技术有限责任公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-114656934-B | Refrigerant circulation device | 大金工业株式会社 | 2024-07-05 | — | — | CN | disclosed |
| CN-114051525-B | Refrigerant-containing composition, use thereof, refrigerator having the composition, method for operating the refrigerator, and refrigeration cycle device having the refrigerator | 大金工业株式会社 | 2024-07-02 | — | — | CN | disclosed |
| CN-113993973-B | Refrigerant-containing composition, use thereof, refrigerator having the composition, method for operating the refrigerator, and refrigeration cycle device having the refrigerator | 大金工业株式会社 | 2024-04-23 | — | — | CN | disclosed |
| CN-116857858-A | Hot water manufacturing device | 大金工业株式会社 | 2023-10-10 | — | — | CN | disclosed |
| CN-116804500-A | Refrigeration cycle device | 大金工业株式会社 | 2023-09-26 | — | — | CN | disclosed |
| CN-116804501-A | Refrigerating device | 大金工业株式会社 | 2023-09-26 | — | — | CN | disclosed |
| CN-116792980-A | Refrigeration cycle device | 大金工业株式会社 | 2023-09-22 | — | — | CN | disclosed |
| EP-0452816-B1 | Use of synthetic lubricating oils in refrigerators | NIPPON OIL CO LTD (JP) | 1994-06-29 | — | — | EP | disclosed |
| EP-0470788-B1 | Synthetic lubricating oil | NIPPON OIL CO LTD (JP) | 1994-04-13 | — | — | EP | disclosed |
| EP-0435253-B1 | Refrigerator oils for use with hydrogen-containing halogenocarbon refrigerants | NIPPON OIL CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5262076-A | Carbonates, refrigerator use, compatible with Freon replacements | NIPPON OIL CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0499793-A1 | Synthetic lubricating oils | NIPPON OIL CO., LTD. (JP) | 1992-08-26 | — | — | EP | disclosed |
| EP-0470788-A1 | Synthetic lubricating oil | Nippon Oil Co., Ltd. (JP) | 1992-02-12 | — | — | EP | disclosed |
| EP-0460614-A1 | Lubricating oils for refrigerators | NIPPON OIL COMPANY, LIMITED (JP) | 1991-12-11 | — | — | EP | disclosed |
| EP-0460613-A1 | Lubricating oils for refrigerators | NIPPON OIL CO. LTD. (JP) | 1991-12-11 | — | — | EP | disclosed |
| EP-0452816-A2 | Use of synthetic lubricating oils in refrigerators | NIPPON OIL CO. LTD. (JP) | 1991-10-23 | — | — | EP | disclosed |
| EP-0435253-A1 | Refrigerator oils for use with hydrogen-containing halogenocarbon refrigerants | NIPPON OIL COMPANY, LIMITED (JP) | 1991-07-03 | — | — | EP | disclosed |