Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL29839700 | 0.95 | ALDH1A1 (0.90) | ALDH1A1MAPK1TAAR1HSD17B10CYP1A2 | |
| Biphenyl SCHEMBL36559 | 0.95 | ALDH1A1 (0.90) | ALDH1A1MAPK1TAAR1HSD17B10CYP1A2 | |
| Biphenyl SCHEMBL1157981 | 0.95 | ALDH1A1 (0.90) | ALDH1A1MAPK1TAAR1HSD17B10CYP1A2 | |
| Biphenyl SCHEMBL1764503 | 0.91 | ALDH1A1 (0.82) | ALDH1A1MAPK1TAAR1HSD17B10CYP1A2 | |
| Biphenyl SCHEMBL983644 | 0.91 | ALDH1A1 (0.82) | ALDH1A1MAPK1TAAR1HSD17B10CYP1A2 | |
| Biphenyl SCHEMBL1069729 | 0.91 | ALDH1A1 (0.82) | ALDH1A1MAPK1TAAR1HSD17B10CYP1A2 | |
| Biphenyl SCHEMBL9634747 | 0.91 | ALDH1A1 (0.82) | ALDH1A1MAPK1TAAR1HSD17B10CYP1A2 | |
| Biphenyl SCHEMBL1150073 | 0.91 | ALDH1A1 (0.82) | ALDH1A1MAPK1TAAR1HSD17B10CYP1A2 | |
| Biphenyl SCHEMBL7053056 | 0.91 | ALDH1A1 (0.82) | ALDH1A1MAPK1TAAR1HSD17B10CYP1A2 | |
| Biphenyl SCHEMBL3857670 | 0.91 | ALDH1A1 (0.82) | ALDH1A1MAPK1TAAR1HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412759-B1 | Heat-curable type resinous composition and moulded article prepared therefrom | NIPPON PAINT CO LTD (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0342064-B1 | A thermosetting resinous composition and preparation of heat resisting coating and molded product using said composition | NIPPON PAINT CO LTD (JP) | 1995-02-15 | — | — | EP | disclosed |
| US-5200540-A | REFINING PROCESS OF ORGANIC TIN (IV) POLYHALIDES | KORIYAMA KASEI CO., LTD. (JP) | 1993-04-06 | — | — | US | disclosed |
| US-5126423-A | Forming heat-resistant moldings of polyoxazolidones; catalyst selectivity | NIPPON PAINT CO., LTD. (JP) | 1992-06-30 | — | — | US | disclosed |
| US-5086152-A | Complex of organs antimory halide and zinc ralide as catalyst | NIPPON PAINT CO., LTD. (JP) | 1992-02-04 | — | — | US | disclosed |
| EP-0412759-A2 | Heat-curable type resinous composition and moulded article prepared therefrom | NIPPON PAINT CO., LTD. (JP) | 1991-02-13 | — | — | EP | disclosed |
| EP-0342064-A2 | A thermosetting resinous composition and preparation of heat resisting coating and molded product using said composition | NIPPON PAINT CO., LTD. (JP) | 1989-11-15 | — | — | EP | disclosed |