Biphenyl

Biphenyl

SCHEMBL1069729

Cl.I.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 known ✓ P31645 1/20 0.47
MAOA known ✓ P21397 1/20 0.45
CA2 known ✓ P00918 1/20 0.45
ALDH1A1 P00352 2/20 0.82
MAPK1 P28482 2/20 0.53
TAAR1 Q96RJ0 2/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
HSD17B10 Q99714 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
NOTUM Q6P988 1/20 0.53
MMP3 P08254 1/20 0.53
BCL2L1 Q07817 1/20 0.53
ATM Q13315 1/20 0.47
SLC22A2 O15244 1/20 0.47
SLC22A1 O15245 1/20 0.47
SLC22A3 O75751 1/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
NFKB1 P19838 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL1157981 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL36559 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL29839700 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL10891000 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL205679 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL8520135 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL10906408 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL13739106 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL11128312 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL9140936 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 443 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4511640-B1 STABLE UV INDICATOR INTELLEGO TECH AB SWEDEN (SE) 2025-12-24 EP claimed
US-20250277748-A1 STABLE UV INDICATOR INTELLEGO TECHNOLOGIES AB (SE) 2025-09-04 US claimed
EP-4511640-A1 STABLE UV INDICATOR Intellego Technologies AB (Sweden) (SE) 2025-02-26 EP claimed
WO-2023203159-A1 STABLE UV INDICATOR Intellego Technologies AB (Sweden) (SE) 2023-10-26 WO claimed
CN-116789887-A Ionic photoacid generator film-forming resin copolymer, preparation method and application 中国科学院福建物质结构研究所 2023-09-22 CN claimed
CN-116068852-B Positive photosensitive resin composition and preparation method and application thereof 明士(北京)新材料开发有限公司 2023-07-14 CN claimed
CN-116068852-A Positive photosensitive resin composition and preparation method and application thereof 明士(北京)新材料开发有限公司 2023-05-05 CN claimed
CN-114129732-B Use of NADPH oxidase 2 inhibitors for the production of medicaments 清华大学 2022-10-25 CN claimed
CN-114479112-A Dendritic eosin B-iodonium salt visible photoinitiator as well as preparation method and application thereof 常熟理工学院 2022-05-13 CN claimed
CN-114478845-A Dendritic fluorescein sodium-iodonium salt visible light initiator and preparation method and application thereof 常熟理工学院 2022-05-13 CN claimed
EP-0884650-A1 Photosensitive recording material using microcapsules Brother Kogyo Kabushiki Kaisha (JP) 1998-12-16 EP claimed
US-5605789-A Iodochloride emulsions containing iodonium salts having high sensitivity and low fog EASTMAN KODAK COMPANY (US) 1997-02-25 US claimed
EP-0718678-A1 Iodochloride emulsions containing iodonium salts having high sensitivity and low fog EASTMAN KODAK COMPANY (US) 1996-06-26 EP claimed
US-5516621-A Photosensitive microcapsule having increased photosensitive sensitivity BROTHER KOGYO KABUSHIKI KAISHA (JP) 1996-05-14 US claimed
US-5506326-A WITH AN AUTOOXIDIZABLE 1,4-DIHYDROPYRIDINE AND A SOLUBLE IONIC SALT LOCTITE (IRELAND) LIMITED (IE) 1996-04-09 US claimed
WO-1994019418-A1 AIR-ACTIVATABLE POLYMERISABLE COMPOSITIONS CONTAINING ONIUM SALTS LOCTITE (IRELAND) LIMITED (IE) 1994-09-01 WO claimed
EP-0611813-A1 Air-activatable polymerisable compositions containing onium salts LOCTITE (IRELAND) LIMITED (IE) 1994-08-24 EP claimed
EP-0224730-B1 ANAEROBIC ADHESIVE COMPOSITIONS National Starch and Chemical Investment Holding Corporation (US) 1992-03-04 EP claimed
EP-0224730-A2 Anaerobic adhesive compositions National Starch and Chemical Investment Holding Corporation (US) 1987-06-10 EP claimed
US-4656229-A CURABLE ACRYLATE, DIARYL IODINIUM SALT CATALYST AND ALDEHYDE-AMINE CONDENSATION PRODUCT AS ACTIVATOR; STORAGE STABILITY NATIONAL STARCH AND CHEMICAL CORPORATION (US) 1987-04-07 US claimed