Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | LOX | P28300 | 1/20 | 0.36 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PMM2 | O15305 | 1/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30185957 | 0.83 | KMT2A (0.46) | SMN1; SMN2KMT2A | |
| SCHEMBL2392823 | 0.83 | HPGD (0.47) | HPGDALDH1A1SMN1; SMN2TDP1MEN1 | |
| SCHEMBL1884032 | 0.83 | KMT2A (0.46) | SMN1; SMN2KMT2A | |
| SCHEMBL8979725 | 0.82 | PARP1 (0.46) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9596990 | 0.81 | HPGD (0.44) | HPGDALDH1A1SMN1; SMN2ERN1KIF11 | |
| SCHEMBL317948 | 0.78 | RAB9A (0.52) | HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9387193 | 0.74 | CYP4F2 (0.49) | HPGDALDH1A1SMN1; SMN2TDP1MEN1 | |
| SCHEMBL5362522 | 0.73 | ALDH1A1 (0.40) | HPGDALDH1A1KMT2ACYP3A4 | |
| SCHEMBL7406706 | 0.73 | MEN1 (0.55) | HPGDALDH1A1SMN1; SMN2TDP1ERN1 | |
| SCHEMBL5953069 | 0.73 | DRD3 (0.40) | ALDH1A1SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| EP-0636129-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | Pfizer Limited (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021178-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |