Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | RGS12 | O14924 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199886 | 0.93 | KDM4E (0.46) | MAPK1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5791367 | 0.86 | CYP2C9 (0.46) | MKNK1MKNK2RAF1MEN1KMT2A | |
| SCHEMBL3208573 | 0.82 | ATM (0.50) | CYP11B1CYP11B2NPC1RAB9AKDM4E | |
| SCHEMBL9194946 | 0.77 | MAPT (0.46) | MAPK1SMN1; SMN2KDM4E | |
| SCHEMBL8979725 | 0.77 | PARP1 (0.46) | MEN1APAF1RGS12HSP90AA1MAPK1 | |
| SCHEMBL8979697 | 0.76 | MAPK1 (0.46) | MEN1APAF1RGS12HSP90AA1MAPK1 | |
| SCHEMBL9349704 | 0.74 | CYP2C9 (0.34) | — | |
| SCHEMBL4069966 | 0.72 | HCAR2 (0.32) | — | |
| SCHEMBL12502235 | 0.72 | CHRNB2 (0.33) | CHRNB2CHRNA4 | |
| SCHEMBL2530451 | 0.72 | GPR84 (0.44) | CYP11B1CYP11B2MEN1APAF1RGS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| EP-0636129-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | Pfizer Limited (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021178-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |