Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6295907 | 0.88 | ALDH1A1 (0.81) | PDE10AALDH1A1KMT2AMEN1THRB | |
| SCHEMBL8980204 | 0.84 | PDE10A (0.73) | PDE10AALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL6300496 | 0.83 | ALDH1A1 (0.82) | ALDH1A1KMT2AMEN1THRBNPC1 | |
| SCHEMBL8980347 | 0.80 | PDE10A (0.56) | PDE10AALDH1A1KMT2AMEN1THRB | |
| SCHEMBL8980401 | 0.80 | ALDH1A1 (0.66) | ALDH1A1KMT2AMEN1THRBNPC1 | |
| SCHEMBL30935740 | 0.78 | KMT2A (1.00) | PDE10AALDH1A1KMT2AMEN1THRB | |
| SCHEMBL8980312 | 0.76 | ALDH1A1 (0.72) | PDE10AALDH1A1KMT2AMEN1THRB | |
| SCHEMBL8980413 | 0.75 | ALDH1A1 (0.70) | ALDH1A1KMT2AMEN1THRBNPC1 | |
| SCHEMBL8980373 | 0.75 | — | — | |
| SCHEMBL19211221 | 0.71 | TAAR1 (0.49) | PDE10AALDH1A1KMT2AMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |