Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 7/20 | 0.68 |
| ▸ | LMNA | P02545 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.68 |
| ▸ | TUBB | P07437 | 2/20 | 0.68 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.68 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.68 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.68 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.68 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.68 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980201 | 0.84 | PDE10A (0.72) | PDE10AHPGDLMNAALDH1A1KDM4E | |
| SCHEMBL2630603 | 0.83 | HPGD (0.76) | PDE10AHPGDLMNAALDH1A1KDM4E | |
| SCHEMBL29411863 | 0.81 | HPGD (1.00) | PDE10AHPGDLMNAALDH1A1KDM4E | |
| SCHEMBL367268 | 0.81 | HPGD (1.00) | PDE10AHPGDLMNAALDH1A1KDM4E | |
| SCHEMBL9385766 | 0.81 | HPGD (0.68) | PDE10AHPGDLMNAALDH1A1KDM4E | |
| SCHEMBL2799465 | 0.81 | HPGD (1.00) | PDE10AHPGDLMNAALDH1A1KDM4E | |
| SCHEMBL6534299 | 0.81 | HPGD (1.00) | HPGDLMNAALDH1A1KDM4ETP53 | |
| SCHEMBL30935740 | 0.81 | KMT2A (1.00) | PDE10AHPGDLMNAALDH1A1KDM4E | |
| SCHEMBL1273139 | 0.81 | HPGD (0.68) | PDE10AHPGDLMNAALDH1A1KDM4E | |
| SCHEMBL8980401 | 0.81 | ALDH1A1 (0.66) | HPGDLMNAALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |