Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25910973 | 0.81 | TUBB4A (0.53) | PDE10AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL8980204 | 0.81 | PDE10A (0.73) | PDE10AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL8980201 | 0.80 | PDE10A (0.72) | PDE10AALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL8980401 | 0.77 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2ATHRBLMNA | |
| SCHEMBL8980306 | 0.77 | NPC1 (0.57) | NPC1 | |
| SCHEMBL29902942 | 0.76 | TUBB4A (0.74) | ALDH1A1MEN1KMT2ATHRBLMNA | |
| SCHEMBL22552101 | 0.76 | TUBB4A (0.74) | ALDH1A1MEN1KMT2ATHRBLMNA | |
| SCHEMBL12049289 | 0.73 | KDM4E (0.45) | ALDH1A1MEN1KMT2ALMNAHPGD | |
| SCHEMBL2466587 | 0.72 | PIM1 (0.56) | KIF11MAPK1 | |
| SCHEMBL5074291 | 0.72 | PARP1 (0.60) | KDM4EKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |