Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | HPGD | P15428 | 4/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.50 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980242 | 0.87 | PDE10A (0.76) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL8980474 | 0.86 | ALDH1A1 (0.72) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL8980346 | 0.84 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL6295907 | 0.81 | ALDH1A1 (0.81) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL6300496 | 0.76 | ALDH1A1 (0.82) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL8980201 | 0.76 | PDE10A (0.72) | ALDH1A1KDM4EHPGDMAPTPDE10A | |
| SCHEMBL10223078 | 0.74 | KDM4E (0.57) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL3204484 | 0.72 | FFAR1 (0.50) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT | |
| SCHEMBL9387850 | 0.72 | KDM4E (0.70) | ALDH1A1KDM4EHPGDSMN1; SMN2PDE10A | |
| SCHEMBL30935740 | 0.71 | KMT2A (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |