Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | CTSV | O60911 | 2/20 | 0.69 |
| ▸ | CTSL | P07711 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.68 |
| ▸ | TUBB | P07437 | 1/20 | 0.68 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.68 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.68 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.68 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.68 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.68 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6295964 | 0.89 | ALDH1A1 (0.81) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL9389628 | 0.87 | LMNA (1.00) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL312265 | 0.84 | SMN1; SMN2 (0.74) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6300496 | 0.84 | ALDH1A1 (0.82) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL2630603 | 0.83 | HPGD (0.76) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6001399 | 0.82 | CTSV (1.00) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL29411879 | 0.82 | CTSV (1.00) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6294903 | 0.81 | ALDH1A1 (0.68) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL29411863 | 0.81 | HPGD (1.00) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL367268 | 0.81 | HPGD (1.00) | HPGDALDH1A1LMNAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029394-B2 | 2-phenyl-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-12 | — | — | US | disclosed |
| US-9029394-B2 | 2-phenyl-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-12 | — | — | US | disclosed |
| US-9023866-B2 | 2-selenophene-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-05 | — | — | US | disclosed |
| US-9023867-B2 | Hydrophilic derivatives of 2-selenophene-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-05 | — | — | US | disclosed |
| US-9023866-B2 | 2-selenophene-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-05 | — | — | US | disclosed |
| US-9023867-B2 | Hydrophilic derivatives of 2-selenophene-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-05 | — | — | US | disclosed |
| US-20130252999-A1 | 2-PHENYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2013-09-26 | — | — | US | disclosed |
| US-20130253006-A1 | 2-SELENOPHENE-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2013-09-26 | — | — | US | disclosed |
| US-20130253006-A1 | 2-SELENOPHENE-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2013-09-26 | — | — | US | disclosed |
| US-20130252999-A1 | 2-PHENYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2013-09-26 | — | — | US | disclosed |
| US-8440692-B2 | Hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2013-05-14 | — | — | US | disclosed |
| EP-2096924-B1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | UNIV CHINA MEDICAL (TW) | 2013-02-13 | — | — | EP | disclosed |
| EP-2468747-A1 | 2-Selenophene-4-quinolones as anticancer agents | China Medical University (TW) | 2012-06-27 | — | — | EP | disclosed |
| EP-2455369-A1 | Derivatives of 2-aryl-4-quinolones having an aminoalkyl group as anticancer agents | China Medical University (TW) | 2012-05-23 | — | — | EP | disclosed |
| US-20100168064-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2010-07-01 | — | — | US | disclosed |
| US-20100168064-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2010-07-01 | — | — | US | disclosed |
| WO-2008070176-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2008-06-12 | — | — | WO | disclosed |
| EP-1088818-B1 | Quinolin-4-yl derivatives | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6440995-B1 | NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS | HOFFMAN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1088818-A1 | Quinolin-4-yl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130253006-A1 | 2-SELENOPHENE-4-QUINOLONES AS ANTICANCER AGENTS | DDX5, DHX30, PPIP5K2 | HPGD 2847/4885ALDH1A1 3657/4885LMNA 4703/4885 |
| US-20100168064-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | DHX30, SLC20A2, DDX20 | HPGD 1886/4885ALDH1A1 3130/4885LMNA 4383/4885 |
| US-20130252999-A1 | 2-PHENYL-4-QUINOLONES AS ANTICANCER AGENTS | PPIP5K2, DDX5, DHX30 | HPGD 2307/4885ALDH1A1 3490/4885LMNA 4539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.