Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.74 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.58 |
| ▸ | TUBB | P07437 | 1/20 | 0.58 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.58 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.58 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.58 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.58 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.58 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25910923 | 0.85 | ALDH1A1 (0.74) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL8980242 | 0.85 | PDE10A (0.76) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL8980474 | 0.84 | ALDH1A1 (0.72) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL8980312 | 0.84 | ALDH1A1 (0.72) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL31237652 | 0.83 | ALDH1A1 (0.82) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL8980401 | 0.79 | ALDH1A1 (0.66) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL8980413 | 0.79 | ALDH1A1 (0.70) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL6295684 | 0.79 | ALDH1A1 (0.81) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL26406079 | 0.79 | MTNR1A (0.66) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL30462987 | 0.78 | HPGD (0.74) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |