Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HMGCR | P04035 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 6/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28806792 | 0.87 | HTT (0.58) | KDM4EALDH1A1MAPTCASP1CASP7 | |
| SCHEMBL1589648 | 0.83 | ADORA2A (0.47) | KDM4EALDH1A1ADORA2ANPC1CYP3A4 | |
| SCHEMBL8981619 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1MAPTCASP1CASP7 | |
| SCHEMBL8980690 | 0.78 | RAB9A (0.58) | KDM4EALDH1A1MAPTCASP1CASP7 | |
| SCHEMBL8980567 | 0.78 | ALDH1A1 (0.61) | KDM4EALDH1A1MAPTCASP1CASP7 | |
| SCHEMBL4579120 | 0.77 | KDM4E (0.68) | KDM4EALDH1A1MAPTCASP1CASP7 | |
| SCHEMBL11946685 | 0.76 | TAS1R3 (0.57) | KDM4EALDH1A1MAPTCASP1CASP7 | |
| SCHEMBL13913242 | 0.76 | APP (0.53) | KDM4EALDH1A1ADORA2AAPPACHE | |
| SCHEMBL9902404 | 0.75 | KMT2A (0.63) | NPC1MEN1KMT2ARXFP1LMNA | |
| SCHEMBL9668883 | 0.75 | SMPD1 (0.61) | KDM4EALDH1A1HTTNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711286-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004048-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |