Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780987 | 0.78 | IRAK4 (0.42) | NNMTSIRT3TDP1IRAK4ALDH1A1 | |
| SCHEMBL8981463 | 0.77 | IRAK4 (0.53) | TDP1IRAK4ALDH1A1MAPTMKNK1 | |
| SCHEMBL5515911 | 0.77 | ERN1 (0.44) | NNMTERN1SIRT3TDP1ALDH1A1 | |
| SCHEMBL28887386 | 0.76 | SIRT3 (0.40) | NNMTSIRT3TDP1IRAK4ALDH1A1 | |
| SCHEMBL9861386 | 0.75 | LMNA (0.33) | ALDH1A1HPGDTSHRGRM1LMNA | |
| SCHEMBL5354600 | 0.75 | ERN1 (0.43) | NNMTERN1SIRT3TDP1ALDH1A1 | |
| SCHEMBL28078633 | 0.73 | ERN1 (0.39) | NNMTERN1IRAK4ALDH1A1HPGD | |
| SCHEMBL23190744 | 0.72 | IRAK4 (0.47) | NNMTERN1SIRT3TDP1IRAK4 | |
| SCHEMBL27484386 | 0.71 | SIRT3 (0.37) | NNMTSIRT3TDP1IRAK4ALDH1A1 | |
| SCHEMBL3424158 | 0.71 | ERN1 (0.54) | NNMTERN1SIRT3TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711286-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004048-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |