Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9794854 | 0.82 | CA1 (0.42) | MEN1KMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL7973009 | 0.82 | MEN1 (0.76) | MEN1KMT2ATDP1L3MBTL1KCNH2 | |
| SCHEMBL9043813 | 0.81 | TDP1 (0.50) | MEN1KMT2ATDP1L3MBTL1KCNH2 | |
| SCHEMBL5166263 | 0.79 | TDP1 (0.66) | KMT2ATDP1L3MBTL1KCNH2HRH3 | |
| SCHEMBL6701399 | 0.79 | TDP1 (0.74) | MEN1KMT2ATDP1L3MBTL1KCNH2 | |
| SCHEMBL7961195 | 0.78 | L3MBTL1 (0.61) | KMT2ATDP1L3MBTL1KCNH2HRH3 | |
| SCHEMBL11546683 | 0.77 | MEN1 (0.59) | MEN1KMT2ATDP1L3MBTL1KCNH2 | |
| SCHEMBL21157703 | 0.77 | RARB (0.64) | MEN1KMT2ATDP1L3MBTL1KCNH2 | |
| SCHEMBL6867384 | 0.77 | TDP1 (0.64) | TDP1L3MBTL1KCNH2HRH3TBXAS1 | |
| SCHEMBL8982266 | 0.77 | CA1 (0.40) | MEN1KMT2ATDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409382-A1 | Glutamic acid derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990014340-A1 | GLUTAMIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-11-29 | — | — | WO | disclosed |
| US-4971973-A | Antitumor agents from polyglutamic acid modified with n- 4- 3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl!propoxyl!benzoyl -glutamic acid | BURROUGHS WELLCOME CO. (US) | 1990-11-20 | — | — | US | disclosed |