SCHEMBL8984690

SCHEMBL8984690

ClC1(Cl)C=Cc2ccccc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNB4 O00305 1/20 0.35
CACNA1A O00555 1/20 0.35
CACNA1G O43497 1/20 0.35
CACNG3 O60359 1/20 0.35
CACNA1F O60840 1/20 0.35
CACNA1H O95180 1/20 0.35
CACNB3 P54284 1/20 0.35
CACNA2D1 P54289 1/20 0.35
CACNG7 P62955 1/20 0.35
CACNA1B Q00975 1/20 0.35
CACNA1D Q01668 1/20 0.35
CACNB1 Q02641 1/20 0.35
CACNG1 Q06432 1/20 0.35
CACNB2 Q08289 1/20 0.35
CACNA1S Q13698 1/20 0.35
CACNA1C Q13936 1/20 0.35
CACNA1E Q15878 1/20 0.35
CACNA2D4 Q7Z3S7 1/20 0.35
CACNA2D3 Q8IZS8 1/20 0.35
CACNG8 Q8WXS5 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18378466 0.76 CACNB4 (0.38) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL10431969 0.76 CACNB4 (0.33) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL8737325 0.76 OXTR (0.33) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL8984508 0.76 ALDH1A1 (0.33)
SCHEMBL1651970 0.74 MAPT (0.42) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL29842453 0.74 GAA (0.36) GAAMAPTHSD11B1OXTRKDM4E
SCHEMBL2826156 0.74 MAPT (0.42) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL2287265 0.74 GAA (0.36) GAAMAPTHSD11B1OXTRKDM4E
SCHEMBL8734930 0.72 KDM4E (0.34) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
Fluoride SCHEMBL1130944 0.71 OXTR (0.33) GAAMAPTOXTRKDM4EPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5387725-A Chlorinating compounds having acidic protons with a perchloro-alkane and aqueous base in the presence of a tetraalkyl-ammonium hydroxide phase transfer catalyst THE DOW CHEMICAL COMPANY (US) 1995-02-07 US claimed
EP-0611366-A1 CHLORINATION PROCESS, ALKYLATION OF PRODUCTS OF SAID PROCESS AND SOME PRODUCTS THEREOF THE DOW CHEMICAL COMPANY (US) 1994-08-24 EP claimed
US-5288915-A Process of making ketones THE DOW CHEMICAL COMPANY (US) 1994-02-22 US claimed
WO-1993009074-A2 CHLORINATION PROCESS, ALKYLATION OF PRODUCTS OF SAID PROCESS AND SOME PRODUCTS THEREOF THE DOW CHEMICAL COMPANY (US) 1993-05-13 WO claimed
WO-1993009082-A1 PROCESS OF MAKING KETONES THE DOW CHEMICAL COMPANY (US) 1993-05-13 WO claimed
US-5578737-A SUBSTITUTED FLUORENES, MONOMERS FOR HIGH PERFORMANCE POLYMERS THE DOW CHEMICAL COMPANY (US) 1996-11-26 US disclosed
US-5387725-A Chlorinating compounds having acidic protons with a perchloro-alkane and aqueous base in the presence of a tetraalkyl-ammonium hydroxide phase transfer catalyst THE DOW CHEMICAL COMPANY (US) 1995-02-07 US disclosed
EP-0611366-A1 CHLORINATION PROCESS, ALKYLATION OF PRODUCTS OF SAID PROCESS AND SOME PRODUCTS THEREOF THE DOW CHEMICAL COMPANY (US) 1994-08-24 EP disclosed
US-5288915-A Process of making ketones THE DOW CHEMICAL COMPANY (US) 1994-02-22 US disclosed
EP-0374054-B1 INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES OBTAINED, THEIR USE AS MEDICINES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1993-10-06 EP disclosed
WO-1993009074-A2 CHLORINATION PROCESS, ALKYLATION OF PRODUCTS OF SAID PROCESS AND SOME PRODUCTS THEREOF THE DOW CHEMICAL COMPANY (US) 1993-05-13 WO disclosed
WO-1993009082-A1 PROCESS OF MAKING KETONES THE DOW CHEMICAL COMPANY (US) 1993-05-13 WO disclosed
EP-0374054-A1 Indane derivatives, process for their preparation and intermediates obtained, their use as medicines, and pharmaceutical compositions containing them ROUSSEL-UCLAF (FR) 1990-06-20 EP disclosed