Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.37 |
| ▸ | CDC25B | P30305 | 8/20 | 0.37 |
| ▸ | MPEG1 | Q2M385 | 7/20 | 0.37 |
| ▸ | CDC25A | P30304 | 6/20 | 0.37 |
| ▸ | CDC25C | P30307 | 5/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | XIAP | P98170 | 2/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | ACP1 | P24666 | 2/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985102 | 0.78 | LMNA (0.33) | ACHEALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL4652217 | 0.74 | THRA (0.37) | ACHEBACE1ALOX5CDC25BMPEG1 | |
| SCHEMBL4651440 | 0.74 | THRA (0.37) | ACHEBACE1ALOX5CDC25BMPEG1 | |
| SCHEMBL6137792 | 0.71 | EPHX1 (0.39) | ACHEBACE1CDC25BCDC25ACDC25C | |
| SCHEMBL5565195 | 0.69 | TDP1 (0.43) | ACHEBACE1ALOX5CDC25BPTPN1 | |
| SCHEMBL11220616 | 0.67 | ACHE (0.45) | ACHEBACE1ALOX5CDC25BCDC25A | |
| SCHEMBL8914982 | 0.63 | TDP1 (0.38) | ACHEBACE1ALOX5CDC25BPTPN1 | |
| SCHEMBL6543575 | 0.61 | ACHE (0.50) | ACHEBACE1ALOX5CDC25BCDC25A | |
| SCHEMBL7029057 | 0.61 | ACHE (0.50) | ACHEBACE1ALOX5CDC25BCDC25A | |
| SCHEMBL4372749 | 0.61 | ACHE (0.50) | ACHEBACE1ALOX5CDC25BCDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541221-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0637240-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES FOR INHIBITING BONE LOSS | ALLERGAN, INC. (US) | 1995-02-08 | — | — | EP | disclosed |
| US-5387606-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN, INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5268387-A | Containing ester or carbamate group | ALLERGAN, INC. (US) | 1993-12-07 | — | — | US | disclosed |
| WO-1993021915-A1 | PHARMACEUTICAL COMPOSITIONS FOR INHIBITING BONE LOSS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES | ALLERGAN, INC. (US) | 1993-11-11 | — | — | WO | disclosed |
| EP-0524979-A4 | 2(5H)-FURANONES SUBSTITUTED IN THE 5 AND OR IN THE 4 POSITION, AS ANTI-INFLAMMATORY AGENTS | — | 1993-03-10 | — | — | EP | disclosed |
| EP-0524979-A1 | 2(5H)-FURANONES SUBSTITUTED IN THE 5 AND OR IN THE 4 POSITION, AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1993-02-03 | — | — | EP | disclosed |
| WO-1991016055-A1 | 2(5H)-FURANONES SUBSTITUTED IN THE 5 AND OR IN THE 4 POSITION, AS ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1991-10-31 | — | — | WO | disclosed |