SCHEMBL8985178

SCHEMBL8985178

N#CNC1(NC#N)C=CC(C(=O)Nc2ccccc2)=CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 2/20 0.38
HDAC8 Q9BY41 2/20 0.38
HDAC6 Q9UBN7 2/20 0.38
POLB P06746 2/20 0.38
MEN1 O00255 4/20 0.37
KMT2A Q03164 4/20 0.37
ALDH1A1 P00352 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
RAB9A P51151 2/20 0.37
NPC1 O15118 1/20 0.37
PTPN1 P18031 2/20 0.36
HDAC1 Q13547 1/20 0.35
LMNA P02545 2/20 0.35
KDM4E B2RXH2 2/20 0.35
TP53 P04637 2/20 0.35
HPGD P15428 2/20 0.35
HTT P42858 2/20 0.35
SIRT1 Q96EB6 1/20 0.35
HSD17B10 Q99714 1/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10339864 0.77 RAB9A (0.41) HDAC2HDAC8HDAC6POLBMEN1
SCHEMBL1413121 0.76 PTPN1 (0.44) HDAC2HDAC8HDAC6POLBMEN1
SCHEMBL27495602 0.75 POLB (0.41) HDAC2HDAC8HDAC6POLBMEN1
SCHEMBL9262918 0.71 ALOX5 (0.42) POLBMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL9267213 0.70 ALOX5 (0.41) HDAC2HDAC8HDAC6POLBMEN1
SCHEMBL9271646 0.70 ALOX5 (0.44) POLBMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL9423170 0.70 TSHR (0.38) MEN1KMT2ASMN1; SMN2RAB9ANPC1
SCHEMBL10426993 0.68 PRMT1 (0.40) HDAC2POLBMEN1KMT2AALDH1A1
SCHEMBL28669837 0.68 MGLL (0.37) ALDH1A1RAB9APTPN1HSD17B10MAPT
SCHEMBL18932697 0.67 PTPN1 (0.46) HDAC2HDAC8HDAC6POLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0476589-B1 Multi-layer wiring substrate and production thereof HITACHI LTD (JP) 1996-06-12 EP disclosed
EP-0476589-A2 Multi-layer wiring substrate and production thereof HITACHI, LTD. (JP) 1992-03-25 EP disclosed