Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5190192 | 0.80 | RAB9A (0.41) | TSHRRAB9ANPC1LMNAMAPT | |
| SCHEMBL29080583 | 0.77 | RAB9A (0.37) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL10339864 | 0.76 | RAB9A (0.41) | TSHRRAB9ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL1413121 | 0.75 | PTPN1 (0.44) | TSHRRAB9ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL27495602 | 0.74 | POLB (0.41) | TSHRRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL8985178 | 0.70 | HDAC2 (0.38) | TSHRRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL9262918 | 0.70 | ALOX5 (0.42) | TSHRRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL9271646 | 0.69 | ALOX5 (0.44) | TSHRRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL9267213 | 0.69 | ALOX5 (0.41) | TSHRRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL28527798 | 0.68 | BCAT2 (0.44) | TSHRRAB9ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278180-A | 4,5-bis(aryl) 4H-1,2,4-triazoles derivatives and analgesic use | ROUSSEL UCLAF (FR) | 1994-01-11 | — | — | US | disclosed |
| EP-0176444-B1 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 4H-1,2,4-TRIAZOLE, TRIAZOLES SO OBTAINED, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1989-02-22 | — | — | EP | disclosed |
| EP-0176444-A1 | Process for the preparation of derivatives of 4H-1,2,4-triazole, triazoles so obtained, their use as medicaments, and pharmaceutical compositons containing them | ROUSSEL-UCLAF (FR) | 1986-04-02 | — | — | EP | disclosed |