Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985209 | 0.94 | SMN1; SMN2 (0.45) | NPC1HPGDSMN1; SMN2OPRD1MAPK14 | |
| SCHEMBL8985323 | 0.94 | MAPK14 (0.52) | NPC1HPGDSMN1; SMN2OPRD1MAPK14 | |
| SCHEMBL8985495 | 0.94 | MAPK14 (0.52) | NPC1HPGDSMN1; SMN2OPRD1MAPK14 | |
| SCHEMBL8985230 | 0.91 | OPRD1 (0.60) | NPC1HPGDSMN1; SMN2OPRD1PTGS1 | |
| SCHEMBL8985416 | 0.89 | NPC1 (0.40) | NPC1HPGDSMN1; SMN2OPRD1MAPK14 | |
| SCHEMBL8985265 | 0.85 | SMN1; SMN2 (0.45) | NPC1HPGDSMN1; SMN2MAPK14PTGS1 | |
| SCHEMBL8985360 | 0.84 | MAPK14 (0.40) | NPC1HPGDSMN1; SMN2MAPK14PTGS1 | |
| SCHEMBL8985541 | 0.84 | MAPK14 (0.56) | NPC1HPGDOPRD1MAPK14PTGS1 | |
| SCHEMBL8985467 | 0.82 | MAPK14 (0.60) | NPC1HPGDSMN1; SMN2OPRD1MAPK14 | |
| SCHEMBL8985272 | 0.81 | MAPK14 (0.52) | NPC1SMN1; SMN2OPRD1MAPK14PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |