Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985360 | 0.87 | MAPK14 (0.40) | SMN1; SMN2NPC1HPGDMAPK1MAPT | |
| SCHEMBL8985251 | 0.87 | MAPK14 (0.47) | NPC1HPGDMAPK1MAPTMAPK14 | |
| SCHEMBL8985263 | 0.86 | NOTUM (0.41) | NPC1MAPK1MAPTMAPK14PTGS1 | |
| SCHEMBL8985239 | 0.85 | NPC1 (0.50) | SMN1; SMN2NPC1HPGDMAPK14PTGS1 | |
| SCHEMBL8985416 | 0.85 | NPC1 (0.40) | SMN1; SMN2NPC1HPGDMAPK1PIK3CA | |
| SCHEMBL8985323 | 0.84 | MAPK14 (0.52) | SMN1; SMN2NPC1HPGDPIK3CAMAPK14 | |
| SCHEMBL8985495 | 0.84 | MAPK14 (0.52) | SMN1; SMN2NPC1HPGDPIK3CAMAPK14 | |
| SCHEMBL8985377 | 0.83 | PTGS2 (0.46) | SMN1; SMN2NPC1HPGDNPSR1PTGS1 | |
| SCHEMBL8985209 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1HPGDMAPTNPSR1 | |
| SCHEMBL8985230 | 0.78 | OPRD1 (0.60) | SMN1; SMN2NPC1HPGDMAPTPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |