Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 2/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985251 | 0.89 | MAPK14 (0.47) | NOTUMMAPTMAPK14L3MBTL1ALDH1A1 | |
| SCHEMBL8985265 | 0.86 | SMN1; SMN2 (0.45) | MAPTMAPK14L3MBTL1MAPK1PTGS1 | |
| SCHEMBL8985257 | 0.76 | MAPK14 (0.52) | NOTUMMAPTMAPK14ALDH1A1MAPK1 | |
| SCHEMBL8985360 | 0.73 | MAPK14 (0.40) | MAPTMAPK14ALDH1A1MAPK1PTGS1 | |
| SCHEMBL8985449 | 0.73 | OPRD1 (0.38) | NOTUMPLAUMAPK14L3MBTL1DAPK3 | |
| SCHEMBL8985370 | 0.72 | MAPK14 (0.53) | MAPK14L3MBTL1ALDH1A1PTGS1NPC1 | |
| SCHEMBL8985537 | 0.72 | MAPK14 (0.51) | NOTUMMAPK14L3MBTL1KDRPTGS1 | |
| SCHEMBL8985510 | 0.72 | MAPK14 (0.67) | NOTUMMAPK14PTGS1PTGS2 | |
| SCHEMBL8985288 | 0.72 | MAPK14 (0.67) | NOTUMMAPK14PTGS1PTGS2 | |
| SCHEMBL8985541 | 0.72 | MAPK14 (0.56) | NOTUMMAPK14L3MBTL1ALDH1A1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |