Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | GSK3A | P49840 | 2/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985338 | 0.90 | MAPK14 (0.46) | OPRD1MAPK14PTGS1PTGS2NOX1 | |
| SCHEMBL8985530 | 0.84 | MAPK14 (0.52) | OPRD1MAPK14PTGS1PTGS2L3MBTL1 | |
| SCHEMBL8985472 | 0.83 | AURKA (0.48) | OPRD1PTGS1PTGS2PIM1KDR | |
| SCHEMBL8985463 | 0.81 | PTGS1 (0.35) | PTGS1PTGS2NOX1L3MBTL1UBE2N | |
| SCHEMBL8985493 | 0.81 | PTGS1 (0.41) | PTGS1PTGS2NOX1L3MBTL1UBE2N | |
| SCHEMBL8985322 | 0.78 | PTGS2 (0.33) | PTGS1PTGS2 | |
| SCHEMBL8985448 | 0.78 | OPRD1 (0.39) | OPRD1MAPK14PTGS1PTGS2L3MBTL1 | |
| SCHEMBL8985239 | 0.76 | NPC1 (0.50) | OPRD1MAPK14PTGS1PTGS2NOX1 | |
| SCHEMBL8985541 | 0.75 | MAPK14 (0.56) | OPRD1MAPK14PTGS1PTGS2L3MBTL1 | |
| SCHEMBL8985263 | 0.73 | NOTUM (0.41) | MAPK14PTGS1PTGS2L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |