Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985608 | 0.93 | MAOB (0.51) | NR4A2MAOBMAOA | |
| Hydrochloric Acid SCHEMBL8985560 | 0.80 | MEN1 (0.48) | NR4A2MAOBMAOASMN1; SMN2 | |
| SCHEMBL8985631 | 0.80 | MAOB (0.58) | NR4A2MAOBMAOASMN1; SMN2NPC1 | |
| SCHEMBL8985602 | 0.80 | MEN1 (0.48) | NR4A2MAOBMAOASMN1; SMN2 | |
| Maleic Acid SCHEMBL8985703 | 0.77 | NR4A2 (0.47) | NR4A2MAOBMAOAALDH1A1PTGES | |
| Fumaric Acid SCHEMBL8985706 | 0.77 | NR4A2 (0.47) | NR4A2MAOBMAOAALDH1A1PTGES | |
| SCHEMBL9116935 | 0.75 | MAOB (0.53) | HRH3NR4A2MAOBMAOANPC1 | |
| Oxalic Acid SCHEMBL9115001 | 0.74 | MAOB (0.56) | HRH3NR4A2MAOBMAOAALOX5 | |
| SCHEMBL8985627 | 0.73 | CARM1 (0.68) | SMN1; SMN2MAPTTP53 | |
| SCHEMBL20197028 | 0.71 | LTA4H (0.54) | NR4A2MAOBMAOAL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550292-A | ANXIOLYTIC AND ANTIDEPRESSANT AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| EP-0666840-A1 | BENZYLAMINE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-08-16 | — | — | EP | disclosed |
| WO-1995006630-A1 | BENZYLAMINE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-09 | — | — | WO | disclosed |