Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HPD | P32754 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8985706 | 1.00 | NR4A2 (0.47) | NR4A2MAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL8985602 | 0.87 | MEN1 (0.48) | NR4A2MAOAMAOBACHEKMT2A | |
| Hydrochloric Acid SCHEMBL8985560 | 0.87 | MEN1 (0.48) | NR4A2MAOAMAOBACHEKMT2A | |
| SCHEMBL8985660 | 0.80 | MAOA (0.51) | NR4A2MAOAMAOBKDM4EPKM | |
| SCHEMBL20314090 | 0.79 | MEN1 (0.46) | NR4A2MAOAMAOBACHEKMT2A | |
| SCHEMBL20314093 | 0.79 | MEN1 (0.45) | NR4A2MAOAMAOBACHEKMT2A | |
| Oxalic Acid SCHEMBL8985649 | 0.77 | HRH3 (0.52) | NR4A2MAOAMAOBALDH1A1PTGES | |
| SCHEMBL9115916 | 0.74 | MAOB (0.50) | NR4A2MAOAMAOBHPDKMT2A | |
| SCHEMBL8985645 | 0.74 | MAOB (0.58) | NR4A2MAOAMAOBHPDKMT2A | |
| SCHEMBL9272104 | 0.74 | BCHE (0.60) | NR4A2MAOAMAOBHPDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550292-A | ANXIOLYTIC AND ANTIDEPRESSANT AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |