Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.44 |
| ▸ | CDC25B | P30305 | 5/20 | 0.44 |
| ▸ | ACP1 | P24666 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30167913 | 1.00 | PTPN1 (0.44) | PTPN1CDC25BACP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26076653 | 0.93 | PTPN1 (0.47) | PTPN1CDC25BACP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21428297 | 0.86 | PTPN1 (0.41) | PTPN1CDC25BACP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8307611 | 0.84 | PTPN1 (0.41) | PTPN1CDC25BACP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3722145 | 0.82 | PTPN1 (0.38) | PTPN1CDC25BACP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL15304876 | 0.82 | PTPN1 (0.40) | PTPN1CDC25BACP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL31551715 | 0.79 | PTPN1 (0.42) | PTPN1CDC25BACP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19510006 | 0.79 | — | — | |
| SCHEMBL25634579 | 0.78 | PTPN1 (0.32) | PTPN1 | |
| SCHEMBL12027602 | 0.76 | RIPK1 (0.36) | PTPN1CDC25BACP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115583935-A | Preparation method of 4- (2, 4, 5-trifluorophenyl) -3-oxybutyrate ester | 浙江工业大学 | 2023-01-10 | — | — | CN | claimed |
| WO-2010122578-A2 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES | MSN LABORATORIES LIMITED (IN) | 2010-10-28 | — | — | WO | claimed |
| WO-2023175492-A1 | NOVEL INTERMEDIATES AND ITS USE IN MANUFACTURING OF SITAGLIPTIN | HIKAL LIMITED (IN) | 2023-09-21 | — | — | WO | disclosed |
| US-20230174461-A1 | METHOD FOR PREPARING CHIRAL 4-ARYL-ß-AMINO ACID DERIVATIVE | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2023-06-08 | — | — | US | disclosed |
| US-20230174461-A1 | METHOD FOR PREPARING CHIRAL 4-ARYL-ß-AMINO ACID DERIVATIVE | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2023-06-08 | — | — | US | disclosed |
| CN-112341332-B | Recycling method of sitagliptin key intermediate degradation waste | 浙江昌明药业有限公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-115583935-A | Preparation method of 4- (2, 4, 5-trifluorophenyl) -3-oxybutyrate ester | 浙江工业大学 | 2023-01-10 | — | — | CN | disclosed |
| CN-115583935-A | Preparation method of 4- (2, 4, 5-trifluorophenyl) -3-oxybutyrate ester | 浙江工业大学 | 2023-01-10 | — | — | CN | disclosed |
| CN-113666904-A | Preparation method of sitagliptin phosphate intermediate | 浙江医药股份有限公司新昌制药厂 | 2021-11-19 | — | — | CN | disclosed |
| US-11174266-B2 | Efficient process for the preparation of sitagliptin | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2021-11-16 | — | — | US | disclosed |
| CN-113636950-A | Preparation method of chiral 4-aryl-beta-amino acid derivative | 浙江医药股份有限公司新昌制药厂 | 2021-11-12 | — | — | CN | disclosed |
| WO-2006104997-A2 | TARTARIC ACID SALTS OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR | MERCK & CO., INC. (US) | 2006-10-05 | — | — | WO | disclosed |
| WO-2006065826-A2 | PROCESS TO CHIRAL BETA AMINO ACID DERIVATIVES BY ASYMMETRIC HYDROGENATION | MERCK & CO., INC. (US) | 2006-06-22 | — | — | WO | disclosed |
| WO-2006033848-A1 | AMORPHOUS FORM OF A PHOSPHORIC ACID SALT OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR | MERCK & CO., INC. (US) | 2006-03-30 | — | — | WO | disclosed |
| WO-2005072530-A1 | NOVEL CRYSTALLINE SALTS OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR | MERCK & CO., INC. (US) | 2005-08-11 | — | — | WO | disclosed |
| WO-2005030127-A2 | NOVEL CRYSTALLINE FORM OF A PHOSPHORIC ACID SALT OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |
| WO-2005020920-A2 | NOVEL CRYSTALLINE FORMS OF A PHOSPHORIC ACID SALT OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR | MERCK & CO., INC. (US) | 2005-03-10 | — | — | WO | disclosed |
| WO-2005003135-A1 | PHOSPHORIC ACID SALT OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR | MERCK & CO., INC. (US) | 2005-01-13 | — | — | WO | disclosed |
| WO-2004085661-A2 | PROCESS TO CHIRAL BETA-AMINO ACID DERIVATIVES | MERCK & CO., INC (US) | 2004-10-07 | — | — | WO | disclosed |
| WO-2004085378-A1 | PROCESS FOR THE PREPARATION OF CHIRAL BETA AMINO ACID DERIVATIVES BY ASYMMETRIC HYDROGENATION | MERCK & CO. INC. (US) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174461-A1 | METHOD FOR PREPARING CHIRAL 4-ARYL-ß-AMINO ACID DERIVATIVE | ENPEP, BCAT2, BCAT1 | PTPN1 4607/4885CDC25B 2785/4885ACP1 996/4885 |
| US-11174266-B2 | Efficient process for the preparation of sitagliptin | DPP4, DPP9, DPP7 | PTPN1 1130/4885CDC25B 3609/4885ACP1 2011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.