Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 | P05091 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 4/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987216 | 1.00 | ALDH2 (0.46) | ALDH2MAOAMAOBPTPN1LTB4R | |
| SCHEMBL5360423 | 0.88 | FAAH (0.52) | PTPN1LTB4RFAAHCYSLTR2CYSLTR1 | |
| SCHEMBL5366170 | 0.88 | FAAH (0.52) | PTPN1LTB4RFAAHCYSLTR2CYSLTR1 | |
| SCHEMBL8987130 | 0.86 | LTB4R (0.58) | PTPN1LTB4R | |
| SCHEMBL9291603 | 0.86 | LTB4R (0.58) | PTPN1LTB4R | |
| SCHEMBL8987122 | 0.84 | ALDH2 (0.46) | ALDH2MAOAMAOBPTPN1LTB4R | |
| SCHEMBL9522369 | 0.80 | LTB4R (0.44) | PTPN1LTB4RFAAH | |
| SCHEMBL19474670 | 0.78 | LTA4H (0.53) | CYSLTR2CYSLTR1PDK2 | |
| SCHEMBL8987309 | 0.75 | LTB4R (0.79) | LTB4R | |
| SCHEMBL7043277 | 0.74 | HRH2 (0.57) | FAAHCYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5492915-A | ANTIINFLAMMATORY AGENTS | RHONE-POULENC RORER S.A. (FR) | 1996-02-20 | — | — | US | disclosed |
| US-5366982-A | Antiinflammatory agents or antihistamines | RHONE-POULENC RORER S.A. (FR) | 1994-11-22 | — | — | US | disclosed |
| EP-0540604-A1 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | Aventis Pharma S.A. (FR) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001675-A2 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |