Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987683 | 0.86 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL8987627 | 0.83 | CYP2C9 (0.47) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL8987514 | 0.82 | HDAC3 (0.61) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL8987649 | 0.82 | MEP1B (0.55) | ALDH1A1BCHEACHEMEP1B | |
| Hydrochloric Acid SCHEMBL9132070 | 0.81 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| P-Xylene SCHEMBL746836 | 0.77 | ALDH1A1 (0.52) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL661277 | 0.76 | PLAAT3 (0.51) | HDAC3HDAC1HDAC2HDAC8 | |
| P-Xylene SCHEMBL6033011 | 0.75 | ALDH1A1 (0.50) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| P-Xylene SCHEMBL18427877 | 0.75 | ALDH1A1 (0.50) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL4367534 | 0.74 | TDP1 (0.50) | HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | claimed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | claimed |
| US-5527955-A | AGONIST OF GAMMA AMINOBUTYRIC ACID | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-06-18 | — | — | US | disclosed |
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | disclosed |
| US-5321047-A | Antidepressant | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-06-14 | — | — | US | disclosed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | disclosed |