Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154270 | 0.81 | ALDH1A1 (0.48) | ALDH1A1GAAPOLBKMT2AKCNN4 | |
| SCHEMBL7877735 | 0.81 | ALDH1A1 (0.48) | OPRD1ALDH1A1GAAPOLBKCNN4 | |
| Hydrochloric Acid SCHEMBL11203276 | 0.80 | ALDH1A1 (0.47) | OPRD1ALDH1A1GAAPOLBKCNN4 | |
| SCHEMBL10962715 | 0.78 | POLB (0.47) | ALDH1A1GAAPOLBAR | |
| SCHEMBL8987693 | 0.76 | OPRD1 (0.52) | OPRD1SIGMAR1 | |
| SCHEMBL7982573 | 0.76 | ALDH1A1 (0.53) | OPRD1SIGMAR1ALDH1A1GAAKMT2A | |
| SCHEMBL8987713 | 0.76 | HDAC3 (0.49) | ALDH1A1GAAPOLBMAOB | |
| SCHEMBL17508109 | 0.76 | ALDH1A1 (0.47) | OPRD1ALDH1A1GAAPOLBMAOB | |
| SCHEMBL154265 | 0.75 | KCNH2 (0.51) | SIGMAR1KDM4EMAOB | |
| SCHEMBL149999 | 0.75 | SIGMAR1 (0.59) | SIGMAR1ALDH1A1TSHRLMNAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527955-A | AGONIST OF GAMMA AMINOBUTYRIC ACID | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-06-18 | — | — | US | disclosed |
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | disclosed |
| US-5321047-A | Antidepressant | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-06-14 | — | — | US | disclosed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | disclosed |