Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830778 | 0.80 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC8MAPK1 | |
| SCHEMBL15862571 | 0.80 | HDAC3 (0.58) | HDAC3HDAC1HDAC2HDAC8MAPK1 | |
| Hydrochloric Acid SCHEMBL8987622 | 0.78 | HDAC3 (0.61) | HDAC3HDAC1HDAC2HDAC8MAPK1 | |
| SCHEMBL13068773 | 0.77 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8MAPK1 | |
| SCHEMBL8987668 | 0.76 | OPRD1 (0.44) | OPRD1SIGMAR1 | |
| SCHEMBL19538211 | 0.75 | MEN1 (0.47) | OPRD1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL27567127 | 0.75 | MEN1 (0.47) | OPRD1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7982573 | 0.75 | ALDH1A1 (0.53) | OPRD1ADRA1ASLC6A3SMN1; SMN2SIGMAR1 | |
| SCHEMBL4327317 | 0.75 | HDAC1 (0.71) | HDAC3HDAC1HDAC2HDAC8MAPK1 | |
| SCHEMBL28878133 | 0.75 | LMNA (0.46) | HDAC3HDAC1HDAC2HDAC8MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | claimed |
| US-5321047-A | Antidepressant | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-06-14 | — | — | US | claimed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | claimed |
| US-5527955-A | AGONIST OF GAMMA AMINOBUTYRIC ACID | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-06-18 | — | — | US | disclosed |
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | disclosed |
| US-5321047-A | Antidepressant | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-06-14 | — | — | US | disclosed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | disclosed |