Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 3/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
| ▸ | PNMT | P11086 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077378 | 0.91 | L3MBTL1 (0.57) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11089154 | 0.91 | CYP1A2 (0.66) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8042005 | 0.89 | L3MBTL1 (0.60) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3932468 | 0.87 | HTR1A (0.54) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30496731 | 0.87 | HTR1A (0.54) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11957894 | 0.87 | PRMT5 (0.54) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6350403 | 0.87 | CYP1A2 (0.53) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL18768854 | 0.86 | CYP1A2 (0.57) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL18130602 | 0.85 | CYP1A2 (0.56) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4024603 | 0.83 | CYP1A2 (0.58) | L3MBTL1CYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527955-A | AGONIST OF GAMMA AMINOBUTYRIC ACID | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-06-18 | — | — | US | disclosed |
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | disclosed |
| US-5321047-A | Antidepressant | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-06-14 | — | — | US | disclosed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | disclosed |