Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.59 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987558 | 0.87 | SIGMAR1 (0.63) | TMEM97SIGMAR1DPP7ALDH1A1HTT | |
| SCHEMBL8987627 | 0.83 | CYP2C9 (0.47) | TMEM97SIGMAR1DPP7ALDH1A1HTT | |
| SCHEMBL9131306 | 0.78 | TMEM97 (0.56) | TMEM97SIGMAR1PYCR1 | |
| SCHEMBL7855918 | 0.77 | SIGMAR1 (0.51) | TMEM97SIGMAR1PYCR1BCHEACHE | |
| SCHEMBL31612490 | 0.76 | SIGMAR1 (0.55) | TMEM97SIGMAR1PYCR1 | |
| SCHEMBL11490047 | 0.76 | SIGMAR1 (0.42) | TMEM97SIGMAR1ALDH1A1HTTRAB9A | |
| SCHEMBL11490044 | 0.76 | SIGMAR1 (0.42) | TMEM97SIGMAR1ALDH1A1HTTRAB9A | |
| SCHEMBL8392169 | 0.75 | PYCR1 (0.55) | TMEM97SIGMAR1DPP7ALDH1A1HTT | |
| SCHEMBL17372614 | 0.75 | TMEM97 (1.00) | TMEM97SIGMAR1ALDH1A1RAB9ALTA4H | |
| SCHEMBL13359820 | 0.75 | CARM1 (0.59) | TMEM97SIGMAR1ALDH1A1RAB9ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | claimed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | claimed |
| US-5527955-A | AGONIST OF GAMMA AMINOBUTYRIC ACID | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-06-18 | — | — | US | disclosed |
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | disclosed |
| US-5321047-A | Antidepressant | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-06-14 | — | — | US | disclosed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | disclosed |